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Compares the patients' scores of UPDRS-III before and six-month after receiving deep brain stimulation for Parkinson's disease under MAC or AAA anesthesia.
Compares the patients' scores of UPDRS-III before and six-month after receiving deep brain stimulation for Parkinson's disease under MAC or AAA anesthesia. Besides, the research also compares the adverse events, LED, dosage of anesthetic drugs, wake-up time, surgical time, Hoehn&Yahr, PQD-39, MMSE, MoCA, HAMA, HAMD and patients' satisfaction between the two groups mentioned above.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MAC anesthesia group | Experimental | Parkinson's disease patients receiving deep brain stimulation under MAC anesthesia. |
|
| AAA anesthesia group | Active Comparator | Parkinson's disease patients receiving deep brain stimulation under AAA anesthesia. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MAC anesthesia | Procedure | Patients receives DBS under monitored anesthesia care. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Scores' change of Unified Parkinson's Rating Scale (part III/motor part) | Compares the scores' change of Unified Parkinson's Rating Scale (part III/motor part) between the two groups. | Before and six-month after DBS. |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Levodopa Equivalent Dose | Compares the change of Levodopa equivalent dose between the two groups. | Before and six-month after DBS. |
| Rates of Adverse Events | Compares the rates of adverse events between the two groups. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Liu Zhiheng, Doctor | Anesthesia department of Shenzhen Second People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shenzhen Second People's Hospital | Shenzhen | Guangdong | 518035 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30629245 | Result | Ho AL, Pendharkar AV, Brewster R, Martinez DL, Jaffe RA, Xu LW, Miller KJ, Halpern CH. Frameless Robot-Assisted Deep Brain Stimulation Surgery: An Initial Experience. Oper Neurosurg. 2019 Oct 1;17(4):424-431. doi: 10.1093/ons/opy395. | |
| 29994938 | Result | Kulikov A, Lubnin A. Anesthesia for awake craniotomy. Curr Opin Anaesthesiol. 2018 Oct;31(5):506-510. doi: 10.1097/ACO.0000000000000625. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| AAA anesthesia |
| Procedure |
Patients receives DBS under asleep-awake-asleep anesthesia. |
|
| Intra-operative. |
| Dosage of Anesthetic Drugs | Compares the dosage of anesthetic between the two groups. | Within surgery. |
| Wake-up Time | Compares the wake-up time between the two groups. | Within surgery. |
| Surgical Time | Compares the surgical time between the two groups. | Within surgery. |
| Hoehn&Yahr | Compares the Hoehn&Yahr classification between the two groups' patients. | Before surgery. |
| Patients' Satisfaction(Visual Analogue Scale) | Compares the scores of patients' satisfaction between the two groups' patients by Using a visual analogue scale. The minimum value is 0 and maximum value is 10. Higher value means greater satisfaction. | 24 hours after surgery. |
| Scores' change of 39-item Parkinson's Disease Questionnaire | Compares the scores' change of 39-item Parkinson's Disease Questionnaire between the two groups. | Before and six-month after DBS. |
| Scores' change of Mini-mental State Examination | Compares the scores' change of Mini-mental State Examination between the two groups. | Before and six-month after DBS. |
| Scores' change of Montreal Cognitive Assessment | Compares the scores' change of Montreal Cognitive Assessment between the two groups. | Before and six-month after DBS. |
| Scores' change of Hamilton Anxiety Scale | Compares the scores' change of Hamilton Anxiety Scale between the two groups. | Before and six-month after DBS. |
| Scores' change of Hamilton Depression Scale | Compares the scores' change of Hamilton Depression Scale between the two groups. | Before and six-month after DBS. |
| 30196173 | Result | Krauss P, Marahori NA, Oertel MF, Barth F, Stieglitz LH. Better Hemodynamics and Less Antihypertensive Medication: Comparison of Scalp Block and Local Infiltration Anesthesia for Skull-Pin Placement in Awake Deep Brain Stimulation Surgery. World Neurosurg. 2018 Dec;120:e991-e999. doi: 10.1016/j.wneu.2018.08.210. Epub 2018 Sep 7. |
| 29351243 | Result | Kochanski RB, Sani S. Awake versus Asleep Deep Brain Stimulation Surgery: Technical Considerations and Critical Review of the Literature. Brain Sci. 2018 Jan 19;8(1):17. doi: 10.3390/brainsci8010017. |
| 28250028 | Result | Ho AL, Ali R, Connolly ID, Henderson JM, Dhall R, Stein SC, Halpern CH. Awake versus asleep deep brain stimulation for Parkinson's disease: a critical comparison and meta-analysis. J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):687-691. doi: 10.1136/jnnp-2016-314500. Epub 2017 Mar 1. |
| 29547091 | Result | Chen T, Mirzadeh Z, Chapple KM, Lambert M, Shill HA, Moguel-Cobos G, Troster AI, Dhall R, Ponce FA. Clinical outcomes following awake and asleep deep brain stimulation for Parkinson disease. J Neurosurg. 2018 Mar 16;130(1):109-120. doi: 10.3171/2017.8.JNS17883. Epub 2018 Mar 16. |
| 29027853 | Result | Chen T, Mirzadeh Z, Chapple KM, Lambert M, Evidente VGH, Moguel-Cobos G, Oravivattanakul S, Mahant P, Ponce FA. Intraoperative test stimulation versus stereotactic accuracy as a surgical end point: a comparison of essential tremor outcomes after ventral intermediate nucleus deep brain stimulation. J Neurosurg. 2018 Aug;129(2):290-298. doi: 10.3171/2017.3.JNS162487. Epub 2017 Oct 13. |
| 28920562 | Result | Sheshadri V, Rowland NC, Mehta J, Englesakis M, Manninen P, Venkatraghavan L. Comparison of General and Local Anesthesia for Deep Brain Stimulator Insertion: A Systematic Review. Can J Neurol Sci. 2017 Nov;44(6):697-704. doi: 10.1017/cjn.2017.224. Epub 2017 Sep 18. |
| 26308514 | Result | Grant R, Gruenbaum SE, Gerrard J. Anaesthesia for deep brain stimulation: a review. Curr Opin Anaesthesiol. 2015 Oct;28(5):505-10. doi: 10.1097/ACO.0000000000000230. |
| 22901609 | Result | Erickson KM, Cole DJ. Anesthetic considerations for awake craniotomy for epilepsy and functional neurosurgery. Anesthesiol Clin. 2012 Jun;30(2):241-68. doi: 10.1016/j.anclin.2012.05.002. Epub 2012 Jul 3. |
| 20937936 | Result | Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol. 2011 Feb;68(2):165. doi: 10.1001/archneurol.2010.260. Epub 2010 Oct 11. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |