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Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.
This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients underwent PET/CT & PET/MRI | Patients with head and neck cancer were underwent PET/CT and PET/MRI for staging, assessment and follow up |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiotherapy | Radiation | Patients have received radiotherapy as a treatment modality for Head and neck cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in Apparent diffusion coefficient value between benign and malignant lesions | Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value. | Baseline |
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Inclusion Criteria:
For healthy subject:
Exclusion Criteria:
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The study population were patients who have been diagnosed with head and neck cancer.
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| Name | Affiliation | Role |
|---|---|---|
| Arpad Kovacs, MD, PhD | University of Pecs | Study Director |
| Cselik Zsolt, MD, PhD | Csolnoky Ferenc Kórház, Veszprém, Hungary | Study Chair |
| Omar Freihat | Doctoral school of health sciences, Pécs University, Hungary | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33640578 | Derived | Freihat O, Toth Z, Pinter T, Kedves A, Sipos D, Cselik Z, Lippai N, Repa I, Kovacs A. Pre-treatment PET/MRI based FDG and DWI imaging parameters for predicting HPV status and tumor response to chemoradiotherapy in primary oropharyngeal squamous cell carcinoma (OPSCC). Oral Oncol. 2021 May;116:105239. doi: 10.1016/j.oraloncology.2021.105239. Epub 2021 Feb 25. | |
| 32771060 |
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Variable used in the study.
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Freihat O, Pinter T, Kedves A, Sipos D, Cselik Z, Repa I, Kovacs A. Diffusion-Weighted Imaging (DWI) derived from PET/MRI for lymph node assessment in patients with Head and Neck Squamous Cell Carcinoma (HNSCC). Cancer Imaging. 2020 Aug 8;20(1):56. doi: 10.1186/s40644-020-00334-x. |