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To better understand the immune response to SARS-CoV-2 infection, we devised a precision immunology approach to systematically study the immune function of different patient cohorts
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| asymptomatic Covid-19 | Patients with confirmed SARS-CoV2 PCR but no clinical symptoms |
| |
| symptomatic Covid-19 | Patients with confirmed SARS-CoV2 PCR and light clinical symptoms |
| |
| severe Covid-19 | Patients with confirmed SARS-CoV2 PCR and severe clinical symptoms with ICU admission |
| |
| healthy controls | Persons with negative SARS-CoV2 PCR |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draw | Other | serial blood draw and subsequent deep immune phenotyping analysis, (ii.) immune activation assays, (iii.) transcriptome and (iv.) epigenome analysis in an overarching (v.) bioinformatics data analysis |
| Measure | Description | Time Frame |
|---|---|---|
| Immune response | Immune response of whole blood stimulation assay with various immune activators will be measured by FACS and multiplex Assay | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with different severity of COVID-19. From asymptomatic to critical illness
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christian Bode, MD | Contact | +49228287 | 14119 | christian.bode@ukbonn.de |
| Folkert Steinhagen, MD | Contact | +49228287 | 14114 | Folkert.Steinhagen@ukbonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Eicke Latz, Prof | Institute of Innate Immunity, Univeristy of Bonn | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn | Recruiting | Bonn | 53127 | Germany |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood including Serum and Immune cells
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |