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This will be a retrospective observational cohort study utilizing the data from the British Columbia Perinatal Data Registry (BCPDR). The BCPDR is a provincially inclusive database that aggregates obstetrics and neonatal variables from all attended births in British Columbia.
The primary objective of this study is to evaluate and contrast the average time interval from the first to second birth for patients with recurrent pregnancy loss compared to healthy controls. Secondarily, the investigators will calculate the cumulative live birth rate in the cohort of women with recurrent pregnancy loss who were \
Recurrent pregnancy loss (RPL) is defined as 2 or more pregnancy losses by the European Society of Human Reproduction and Embryology and affects 2-5% of the population. RPL can be further classified into primary and secondary pregnancy losses, with secondary RPL diagnosed when one has achieved a previous live birth. RPL is a frustrating and distressing condition as nearly 50% of patients have no medical explanation for the cause of pregnancy loss. For these patients, research regarding the prognosis and time to live birth is essential.
This will be a retrospective observational cohort study utilizing the data from the British Columbia Perinatal Data Registry (BCPDR). The BCPDR is a provincially inclusive database that aggregates obstetrics and neonatal variables from all attended births in British Columbia. Since April 2000, there are up to 700, 000 births included in this database. The study population will be divided into 4 groups: those without RPL (control group), all patients with RPL, primary RPL, and secondary RPL. Within the RPL group, primary RPL is defined by those with >/=2 pregnancy loss before 20 weeks gestational age before the first birth and the remaining patients will make up the secondary RPL group.
The following demographic variables will be requested: age at first delivery, age at second delivery, the average number of pregnancy loss before first birth, number of pregnancy loss before second birth, BMI at first delivery, BMI at second delivery, principle residence, use of in vitro fertilization to conceive, obstetrical status (number of pregnancies, term deliveries, preterm deliveries, miscarriages, and living children) at first and second birth, school years completed, smoking, at-risk alcohol use, preexisting hypertension, preexisting diabetes, psychiatric illnesses, the number of infant(s) born in first and second delivery, live birth/stillbirth. Primary outcome variables include the date (year, month, and day) of delivery for the first and second live births.
For our second objective, the investigators will analyze the cumulative live birth rate of a subgroup who is \
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Recurrent pregnancy loss | All women with >/=2 pregnancy loss before 20 weeks gestational age |
| |
| Primary recurrent pregnancy loss | Primary RPL is defined by those with >/=2 pregnancy loss before 20 weeks gestational age before the first birth |
| |
| Secondary recurrent pregnancy loss | Secondary RPL is defined by those with >/=2 pregnancy loss before 20 weeks gestational age occurring after the first birth |
| |
| No history of recurrent pregnancy loss | Those with 0 or 1 previous spontaneous pregnancy loss. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Recurrent pregnancy loss | Other | As described before. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time between first birth and second birth | Time interval in Weeks | Time between first birth and second birth during 2000-2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Live birth rate | Proportion of patients achieving second live birth | 10 years after first live birth |
| Obstetrical outcomes | Gestational age at birth, antepartum hemorrhage, pregnancy-induced hypertension, intrauterine growth restriction, diabetes in pregnancy, mode of delivery, birth weight, maternal need for transfusion at delivery, sex of infant, APGAR at 5 and 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Those included in a provincially inclusive database that aggregates obstetrics and neonatal variables from all attended births in British Columbia from 2000-2018
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed A. Bedaiwy, FACOG, FRCSC | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BC Women's Hospital & Health Centre | Vancouver | British Columbia | V6H 3N1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38390658 | Derived | Cho K, Fayek B, Liu YD, Albert A, Wiesenthal E, Dobrer S, AbdelHafez FF, Lisonkova S, Bedaiwy MA. A history of recurrent pregnancy loss is associated with increased perinatal complications, but not necessarily a longer birth interval: a population study spanning 18 years. Hum Reprod. 2024 May 2;39(5):1105-1116. doi: 10.1093/humrep/deae029. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 12, 2024 | |
| Reset | Aug 14, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 12, 2024 | Aug 14, 2024 |
| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| D000026 | Abortion, Habitual |
| D011248 | Pregnancy Complications |
| ID | Term |
|---|---|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Live births during 2000-2020 |