Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of the project is to establish the association between presbycusis and the incidence of frailty in humans in order to establish hearing loss with age as another index for the diagnosis of frailty; As well as studying the effect of exposure to polyphenols in the diet on presbycusis and frailty. Human study: volunteers between 60 and 99 years old, men and women during a period of 6 months, questions and answers, audiometries, study of fragility, analysis of antioxidants in blood, and samples of urine will be measured Total polyphenols and oxidant capacity.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Auditory function | study by pure tone audiometry, calculating an average of the thresholds of hearing at 0.5, 1, 2 and 4 kilohertz classifying according to their hearing thresholds to the participants in: normal hearing ≤ 25decibel, slight hearing loss = 26-40 decibel; Y moderate-greater hearing loss> 40 decibel (according to the World Health Organization). | 6 months |
| Frailty | Fragility will be determined at the beginning and at the end of the study period using the 5 Fried indexes: weakness, low speed, low physical activity, exhaustion and weight loss. Participants with 3 or more criteria are classified as fragile, with 1-2 criteria as pre-fragile, and those without any criteria are not considered fragile. Thus, individuals will be classified in the analyzes as non-fragile, pre-fragile and fragile. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of total polyphenols in urine | 24-hour urine samples using the method Folin -Ciocalteu. | measured twice in each volunteer, at the beginning and end of the study period (6 months) |
| Blood analysis, |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
People who meet the inclusion and exclusion criteria and who attend the ENT or geriatrics clinic
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| RodrÃguez | Contact | 91- 683 93 60 | 2397 | carolina.sanchez2@universidadeuropea.es |
| Name | Affiliation | Role |
|---|---|---|
| Carolina S RodrÃguez | Universidad Europea de Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario de Getafe | Recruiting | Getafe | Madrid | 28905 | Spain |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D011304 | Presbycusis |
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D006319 | Hearing Loss, Sensorineural |
| D034381 | Hearing Loss |
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
routine biochemistry and determination of: carotenoids, vitamins E and D
| It will be performed at the beginning and at end of the study period (6 months) |
| Microbiota | Stool microbiota analysis | It will be performed at the beginning and at end of the study period (6 months) |
| D010038 |
| Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |