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Patients with repaired tetralogy of Fallot (RTOF) develop chronic pulmonary regurgitation and require monitoring for right ventricular dilatation. Pulmonary valve replacement can prevent irreversible right ventricular (RV) dilatation and dysfunction and cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. The investigators sought to determine whether the choice of myocardial contouring technique affects preoperative RV volumetric thresholds for intervention.
Participants with repaired tetralogy of Fallot (RTOF) will be identified using existing patient electronic records who have developed chronic pulmonary regurgitation and are undergoing monitoring for right ventricular dilatation. Cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. Pulmonary valve replacement can prevent irreversible right ventricular (RV) dilatation and dysfunction and cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. There are different post-processing techniques published for measuring RV volumes on cardiac magnetic resonance imaging (detailed vs. smoothed and manual vs. automated). The primary aim of this study is to identify whether the choice of myocardial contouring technique affects the preoperative RV volumetric thresholds for intervention. As a secondary aim, the investigators will determine the reproducibility of different contouring methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Repaired Tetralogy of Fallot | Patients undergoing routine clinical aand CMR surveillance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac MRI | Diagnostic Test | For clinical surveillance |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in the baseline measurement of indexed right ventricular end-diastolic volume according to the contouring technique | Measurements of indexed right ventricular end-diastolic volume will be repeated using different contouring techniques on the same cardiac MRI study performed at baseline pre-surgery. | Cross-sectional study. Repeated measurements performed on the baseline CMR study. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with repaired tetralogy of Fallot (RTOF) with chronic pulmonary regurgitation who require monitoring for right ventricular dilatation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Freya Lodge | Contact | freya.lodge@uhb.nhs.uk | ||
| William Moody | Contact | william.moody@nhs.net |
| Name | Affiliation | Role |
|---|---|---|
| William Moody | UHB | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| QEHB | Recruiting | Birmingham | B15 2TH | United Kingdom |
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| ID | Term |
|---|---|
| D013771 | Tetralogy of Fallot |
| ID | Term |
|---|---|
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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| Cardiac MRI department, University Hospitals Birmingham NHS Foundation Trust | Recruiting | Birmingham | United Kingdom |
|
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |