Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Centro Hospitalar Lisboa Ocidental | OTHER_GOV |
| Centro Hospitalar De São João, E.P.E. | OTHER |
| CUF Academic and Research Medical Center | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Elderly, hypertension, diabetes and cardiovascular diseases are risk factors for COVID-19 morbility and mortality. However, the real reason for this is not yet understood. It is well documented that gut microbiota has a critical role in health, particularly in the immune system and therefore, we propose that gut microbiota composition could affect vulnerability and disease outcomes of COVID-19.
In order to explore this hypothesis, we will analyse the gut microbiota of SARSCoV-2 infected patients categorized according to location: [1] ambulatory (self-isolation at home), [2] ward and [1] ICU; and severity.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ambulatory | Patients that are self-isolated at home |
| |
| Ward | Patients that are in an isolated room at the hospital |
| |
| ICU | Patients that are in the ICU of the hospital |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure | Other | Individuals with SARS-CoV-2 exposure and COVID-19 symptoms. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in gut microbiota composition between COVID-19 patients with different degrees of disease severity. | Stool samples of COVID-19 patients will be collected after subject enrollment (single point collection) |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in gut microbiota composition between COVID-19 patients in relation to mortality. | Through study completion, an average of 3 months. | |
| Differences in gut microbiota composition between COVID-19 patients in relation to length of stay in hospitals. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
COVID-19 patients admitted to Portuguese hospitals.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Conceição Calhau, PhD | Universidade Nova de Lisboa | Principal Investigator |
| Pedro Póvoa, PhD | Hospital São Francisco Xavier | Principal Investigator |
| Cristina Granja, PhD | Centro Hospitalar De São João, E.P.E. | Principal Investigator |
| Maria JR Sousa, PhD | Centro de Medicina Laboratorial Germano de Sousa, S.A. | Principal Investigator |
| José Leal, PhD | Centro de Medicina Laboratorial Germano de Sousa, S.A. | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital CUF Infante Santo, S.A. | Lisbon | Portugal | ||||
| Hospital de São Francisco Xavier |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
| Hospital CUF Infante Santo, S.A. |
| UNKNOWN |
| Centro de Medicina Laboratorial Germano de Sousa, S.A. | UNKNOWN |
| CINTESIS - Center for Health Technology and Services Research | UNKNOWN |
Not provided
Not provided
Not provided
| Through study completion, an average of 3 months. |
| Differences in gut microbiota composition between COVID-19 patients in relation to duration of mechanical ventilation. | Through study completion, an average of 3 months. |
| Lisbon |
| Portugal |
| Centro Hospitalar Universitário São João | Porto | Portugal |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |