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Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heparin with a concentration of 2 U/ml | Experimental | heparin dilution is placed in a pressure bag with a pressure of 300 mmHg |
|
| Heparin with a concentration of 4 U/ml | Experimental | heparin dilution is placed in a pressure bag with a pressure of 300 mmHg |
|
| normal saline | Placebo Comparator | normal saline is placed in a pressure bag with a pressure of 300 mmHg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heparin | Drug | heparin with a concentration of 2 U/ml is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube |
|
| Measure | Description | Time Frame |
|---|---|---|
| The level of glass bead Activated Clotting Time | 10 min after the vein puncture, 2 h after skin incision and at the end of surgery | through study completion, an average of 3 minute |
| Measure | Description | Time Frame |
|---|---|---|
| The level of glass bead Clot Rate | 10 min after the vein puncture, 2 h after skin incision and at the end of surgery | through study completion, an average of 3 minute |
| The level of glass bead Platelet Function |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Affiliated Hospital of Yangzhou University, Yangzhou University | Yangzhou | Jiangsu | 225012 | China |
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| Heparin | Drug | heparin with a concentration of 4 U/ml is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube |
|
| normal saline | Drug | normal saline is used for pressurized continuous flushing of the invasive arterial pressure monitoring tube |
|
10 min after the vein puncture, 2 h after skin incision and at the end of surgery
| through study completion, an average of 3 minute |
| The level of platelet count | 24 h after surgery and 48 h after surgery | through study completion, an average of 2 minute |
| The frequencies of hand positional changes and manual artery flushing | intraoperative |
| The amount of infusion volume, blood loss, urine volume | intraoperative |
| The appearance of local complications of arterial puncture | Yes or No | within 24 h after surgery |
| ID | Term |
|---|---|
| D006493 | Heparin |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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