Compartmental Inflammation in Mechanically Ventilated Patients With COVID-19

Early and Late Pulmonary and Systemic Inflammation in Critically Ill, Mechanically Ventilated Patients With Verified COVID-19

The aim of the present study is to examine the inflammatory response in the pulmonary compartment and blood of critically ill patients admitted to the ICU with COVID-19.

The mechanisms of the ARDS-like respiratory failure observed in patients with COVID-19 are currently unknown, but may be related to a distinct local immune response within the lung. In the present study, we will examine the cellular and humoral pulmonary immune response in mechanically ventilated patients admitted to the ICU with COVID-19 by examining immune cell profiles, cytokine patterns, and the complement pathway in bronchoalveolar lavage fluid, and relate it to the concomitant systemic inflammatory response. We will examine the patients on day 1-3 and 7-9 after ICU admission.

Inclusion Criteria:

• Age > 18y
• Mechanical ventilation
• Verified COVID-19 (throat swab or tracheal aspirate positive for SARS-CoV-2)
• ARDS according to the Berlin definition

Exclusion Criteria:

• Untreated malignant tachycardia or bradycardia
• Suspected or verified intracranial hypertension (ICP > 15 mmHg)
• Unilateral lung ventilation
• Severe non-correctable coagulopathy