Immune Response Features in Allergic Airway Diseases

Investigation of Phenotypes, Endotypes and Immune Response Features in Allergic Airway Diseases

This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.

Inclusion Criteria:

• Hypersensitivity to house dust mites
• Allergic rhinitis with or without mild to moderate asthma

Exclusion Criteria:

• Acute or chronic infections
• Use of systemic immunosupresants (wait 1 month)
• Use of systemic or local antihistamines (wait 1 week)
• Use of intranasal steroids (wait 1 month)
• Oncological or active autoimmune diseases