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This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully investigated yet. Patients with the same disease have different dominant symptoms, course of the disease and response to treatment. Moreover, there is a hypothesis about united airway disease suggesting that allergic rhinitis and allergic asthma is different manifestation of the same disease. This led to assumption of phenotypes and endotypes. This classification which still is not unified can let to prescribe personalized treatment for every patient.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Allergic rhinitis patients |
| ||
| Allergic rhinitis and asthma patients |
| ||
| Healthy individuals |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasal provocation test | Procedure | Allergen extract under controlled conditions will be applied into nasal mucous. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups. | Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites. Comparison between different groups. | 2 hours |
| Cytokines level in nasal lavage and peripheral blood after nasal provocation test in different groups. | Cytokines (IL-13, IL-10, IL-22, etc.) level will be measured by ELISA before and after nasal provocation test with house dust mites. | 22 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with allergic rhinitis with or without asthma and healthy individuals for control group.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laura Tamasauskiene, MD | Contact | +37061569127 | lau.tamasauskiene@gmail.com | |
| Brigita Sitkauskiene | Contact | brigita.sitkauskiene@kaunoklinikos.lt |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital of Lithuanian University of Health Sciences Kauno klinikos | Recruiting | Kaunas | Lithuania |
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| ID | Term |
|---|---|
| D065631 | Rhinitis, Allergic |
| ID | Term |
|---|---|
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
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| D010038 |
| Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |