Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This observational study is designed to assess whether focused lung ultrasound examination can improve the diagnosis of COVID-19 lung disease and/or make an alternative diagnosis at a patient's initial hospital presentation. For patients with confirmed COVID-19 the study will also assess whether surveillance lung ultrasound examination can predict clinical outcome over the course of their hospital admission.
Study participants will be screened from and recruited on their entry into the suspected COVID-19 admission pathway at Derriford Hospital, Plymouth, UK. In addition to usual clinical care (including physical exam and observations, blood tests, nasopharyngeal swab for viral PCR testing, and chest x-ray as standard), participants will undergo focused lung ultrasound examination.
Participants who are negative for COVID-19 will be followed up to confirm their final discharge diagnoses, and clinical outcome at either 3 months post-enrolment or discharge from hospital.
Participants who are positive for COVID-19 will have regular focused lung ultrasound examination during their hospital admission in addition to usual clinical care until their treatment for COVID-19 is complete. Their discharge diagnoses and clinical outcome at either 3 months post-enrolment or discharge from hospital (whichever is later).
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung ultrasound | Diagnostic Test | Focused lung ultrasound examination |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnosis of COVID-19 on lung ultrasound | Primary and blinded scorer diagnosis of COVID-19 on lung ultrasound | On day of admission to hospital |
| Difference in diagnosis of COVID-19 on lung ultrasound vs. chest x-ray | Primary and blinded scorer diagnosis of COVID-19 on lung ultrasound vs. radiologist-reported chest x-ray findings | On day of admission to hospital |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnosis of alternative condition to COVID-19 on lung ultrasound vs. chest x-ray | Primary and blinded scorer diagnosis of alternative condition on lung ultrasound | On day of admission to hospital |
| Ability of surveillance lung ultrasound to predict clinical trajectory / outcome in patients with COVID-19 |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Adult patients (greater than or equal to 18 years in age) presenting with suspected COVID-19
Not provided
| Name | Affiliation | Role |
|---|---|---|
| John P Corcoran, BMBCh MRCP | University Hospital Plymouth NHS Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Derriford Hospital | Plymouth | Devon | PL6 8DH | United Kingdom |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Comparison of lung ultrasound findings with clinical markers of COVID-19 disease severity e.g. supplementary oxygen requirements |
| During hospital admission |
| Consistency of lung ultrasound interpretation in patients presenting with suspected COVID-19 | Comparison of primary and blinded scorer evaluation of lung ultrasound scans for consistency of interpretation and diagnosis | On day of admission to hospital |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |