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Sedation is often required for pediatric medical imaging procedures to ensure compliance and quality images. Recommendations exist regarding pediatric sedation, but there are currently no guidelines regarding the choice of the sedative drug. We aim to compare the efficacy and adverse events of per os pentobarbital with intravenous chlorpromazine in children undergoing diagnostic imaging procedures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chlorpromazine |
| ||
| Pentobarbital |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chlorpromazine or Pentobarbital | Drug | Sedation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sedation success | Imaging purpose is answered | During the procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Induction time | Length of time required after the administration to achieve adequate sedation | During the procedure |
| Hospitalization duration | Length of time from planned time of admission to discharge |
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Inclusion Criteria:
Exclusion Criteria:
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Children undergoing sedation for the purpose of imaging in the pediatric department of Brest hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juliette ROPARS, MD | Contact | 02 98 22 33 89 | +33 | juliette.ropars@chu-brest.fr |
| Name | Affiliation | Role |
|---|---|---|
| Juliette Ropars, MD | Brest University Hospital in France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU de Brest | Brest | 29609 | France |
|
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| ID | Term |
|---|---|
| D002746 | Chlorpromazine |
| D010424 | Pentobarbital |
| ID | Term |
|---|---|
| D010640 | Phenothiazines |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
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| Through procedure completion |
| Duration of the imaging procedure | Length of acquisition time from the first to the last images | During the procedure |
| Secondary effects | Number of participant developing any secondary effects | From Procedure until 2 days after |
| Failure of pentobarbital sedation in children older than 5 years | Comparison of the rate of failure of pentobarbital sedation in children older than 5 years compared to those younger. | During the procedure |
| Failure of pentobarbital sedation in children with a behavioral disorder | Comparison of the rate of failure of pentobarbital sedation in children with a behavioral disorder compared to those without | During the procedure |
| Failure of pentobarbital sedation in children under chronic antiepileptic treatment | Comparison of the rate of failure of pentobarbital sedation in children under chronic antiepileptic treatment compared to those without | During the procedure |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D001463 | Barbiturates |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |