Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases

Fast Troponin as a Biomarker to Assess Exercise-induced Muscle Damage in Muscle Diseases

The purpose of the study is to explore the biomarker Fast Troponins response to exercise in patients with Becker muscular dystrophy, Limb-girdle muscular dystrophy and McArdle disease

Inclusion Criteria:

• The ability to cycle
• No concurrent medical condition that could interfere with interpretation of the results
• Molecular diagnosis of the specific condition in specified patient groups or healthy control
• No active muscle injury on the test day (caused by recent exercise, seizures, trauma, etc.)

Exclusion Criteria:

• Competing conditions at risk of compromising the results of the study
• Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise
• Veins that are too difficult to puncture for blood sampling, evaluated by the investigator
• Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator