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| ID | Type | Description | Link |
|---|---|---|---|
| 2015/2331 | Other Identifier | CSET number |
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Multicentric interventional prospective study with collection of biological samples as part of a routine care research
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with cancer | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tissue sampling | Procedure | Collection of a sample of tumor tissue and a sample of adjacent or counter lateral healthy tissue (if possible) from the surgical room |
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| Measure | Description | Time Frame |
|---|---|---|
| Immunophenotyping of immune infiltrates by flow cytometry | Immunophenotyping analysis by flow cytometry (Cyan, Beckman Coulter): identification of several immune sub-populations (T-B-NK lymphocytes, myeloid and tumor cells); identifications of several receptors and ligands (PD1 / PDL1, Tim-3 / HAVCR2,, CTLA-4, 4-1BB / 4-1BBL, Fas / FasL, TRAIL, OX40 / OX40L, ICOS / ICOSL, CD69, CD25 / CD127, NKp46 / NKp30, NKG2D / NKG2DL, galectin-9, MHC class I and II, B7H3 / B7H6); identification of memory subpopulations (CD45RA / CD27 / CCR7) and, if available, intra-cytoplasmic labeling (CXCR3, CCR6, Granzyme B, KI67, TNFα IFNg, IL-17 and IL-21). | Up yo one year |
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Inclusion Criteria:
Patients treated for immune complications by immunosuppressants may be included (corticosteroids, etc.).
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laurence ZITVOGEL, MD, PhD | Contact | 0142114211 | +33 | laurence.zitvogel@gustaveroussy.fr |
| Agathe DUBUISSON, PhD | Contact | 0142114211 | +33 | agathe.dubuisson@gustaveroussy.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gustave Roussy | Recruiting | Villejuif | Val De Marne | 94800 | France |
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| Blood sampling | Procedure | Collection of a 30mL peripheral blood sample in heparin at several times: during surgical and medical treatment (before surgery, before the start of mAbs and after mAbs) |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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