Honey & Nigella Sativa Trial Against COVID-19

The Role of Honey and Nigella Sativa in the Management of COVID-19; A Randomized Controlled, Open-label, Add-on Trial in Pakistan

To evaluate the effectiveness of Nigella Sativa and honey stirred in 250 ml of distilled water 12 hourly till patient becomes asymptomatic or a maximum of 14 days with standard hospital care versus standard hospital care alone with placebo capsule and 250 ml water, in clearing the COVID-19 nucleic acid from throat and nasal swab, lowering disease detrimental effects on HRCT chest/X-ray and severity of symptoms along with duration of hospital stay till day 14th day of follow up and 30 days mortality (primary outcomes).

This cohort, adaptive, randomized, double armed group, controlled, Investigator Initiated interventional study is designed to demonstrate the superiority of a combination of black cumin with honey over standard care in SARS-CoV-2 (COVID-19) infected patients who consent to randomization following a new diagnosis in Pakistan with an SSC-2 score of > 5 with positive RT-PCR of COVID-19.

Inclusion Criteria:

• Confirmed SARS-CoV-2 (COVID-19) infection by a positive test result with SSC-2 score> 5
• Patients admitted in Corona centers

Exclusion Criteria:

• Participants not giving consent.
• Pregnant and lactating females.
• History of allergy to any drug being administered in this study
• Severely terminally ill patients
• Patients on Nil Per Oral