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This is an open-label, multi-center study to evaluate the anti-tumor activity and safety of camrelizumab combined famitinib in subjects with selected advanced solid tumor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| camrelizumab combined with famitinib | Experimental | Participants will receive camrelizumab on Day 1of each cycle and famitinib qd up to 2 years. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Camrelizumab | Drug | Intravenous (IV) camrelizumab on Day 1 of each cycle |
|
| Measure | Description | Time Frame |
|---|---|---|
| Response Rate | Response Rate | Up to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| PFS | Progression-free Survival | Up to 18 months |
| DOR | Duration of Response | Up to 18months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fudan University Zhongshan Hospital | Shanghai | Shanghai Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42165088 | Derived | Xu B, Zhu G, Lu J, Zhang X, Chen X, Liu Q, Qu S, Fan J, Liu T. Camrelizumab Plus Famitinib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Phase 2 Study. Cancer Med. 2026 May;15(5):e71899. doi: 10.1002/cam4.71899. | |
| 39872476 | Derived | Ai L, Li Q, Zhang S, Dong Y, Yang M, Li J, Pan Y, Yuan Y, Yi S, Wang J, Cheng Y, Feng J, Gao S, Wang X, Qu S, Zhang X, Lu J, Xiu P, Wang S, Yang X, Yu Y, Liu T. Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study. Innovation (Camb). 2025 Jan 6;6(1):100745. doi: 10.1016/j.xinn.2024.100745. eCollection 2025 Jan 6. |
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| ID | Term |
|---|---|
| C000631724 | camrelizumab |
| C584390 | famitinib |
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| Famitinib | Drug | famitinib po qd |
|
| DCR | Disease Control Rate | Up to 18months |
| TTR | Time to Response | Up to 18 months |
| OS | overall survival rate | Up to 18 months |
| The incidence and severity of adverse events (AEs) and serious adverse events (SAEs) as assessed by CTCAE v5.0 | The incidence and severity of adverse events (AEs) and serious adverse events (SAEs) as assessed by CTCAE v5.0 (SAEs) as assessed by CTCAE v5.0 | Up to 18 months |
| Proportion of dose suspension, dose reduction or dose discontinuation caused by treatment-related toxicities. | Proportion of dose suspension, dose reduction or dose discontinuation caused by treatment-related toxicities. | Up to 18 months |
| Proportion of anti-camrelizumab antibody (ADA) and neutralizing antibody (Nab) formed during the study from baseline | Proportion of anti-camrelizumab antibody (ADA) and neutralizing antibody (Nab) formed during the study from baseline | Up to 18 months |
| Serum concentration of camrelizumab | Serum concentration of camrelizumab | Up to 18 months |
| Plasma concentration of famitinib | Plasma concentration of famitinib | Up to 18 months |
| 38388167 | Derived | Ren S, Wang X, Han BH, Pan Y, Zhao J, Cheng Y, Hu S, Liu T, Li Y, Cheng Y, Feng J, Yi S, Gu S, Gao S, Luo Y, Liu Y, Liu C, Duan H, Wang S, Yang X, Fan J, Zhou C. First-line treatment with camrelizumab plus famitinib in advanced or metastatic NSCLC patients with PD-L1 TPS >/=1%: results from a multicenter, open-label, phase 2 trial. J Immunother Cancer. 2024 Feb 21;12(2):e007227. doi: 10.1136/jitc-2023-007227. |
| 37415845 | Derived | Ding X, Hua YJ, Zou X, Chen XZ, Zhang XM, Xu B, Ouyang YF, Tu ZW, Li HF, Duan CY, Zhang WJ, You R, Liu YP, Liu YL, Yang Q, Huang PY, Wang SN, Fan J, Chen MY. Camrelizumab plus famitinib in patients with recurrent or metastatic nasopharyngeal carcinoma treated with PD-1 blockade: data from a multicohort phase 2 study. EClinicalMedicine. 2023 Jun 23;61:102043. doi: 10.1016/j.eclinm.2023.102043. eCollection 2023 Jul. |