Oral Sedation in Vitreoretinal Surgery

Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block

The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.

After being informed about the study and potential risks, and providing written informed consent, a total of 40 patients will undergo vitreoretinal surgery with oral Triazolam and 40 patients will undergo vitreoretinal surgery with intravenous sedation. The IV sedative will be determined by the anesthesiologist or certified registered nurse anesthetist but limited to midazolam, propofol, and fentanyl. The study will be a prospective, cross-sectional study with a 1:1 randomized procedure and unmasked.

Inclusion Criteria:

• Undergoing vitreoretinal surgery for a variety of indications including, but not limited to, epiretinal membrane (ERM), macular hole, vitreous opacities, vitreous hemorrhage, aphakia, dislocated or displaced intraocular or crystalline lens, silicone removal, endolaser, and retinal detachment.
• American Society of Anesthesiologists rating of I-III

Exclusion Criteria:

• Undergoing vitreoretinal surgery requiring general anesthesia
• Allergy or hypersensitivity to benzodiazepines
• Pregnant or nursing females
• Previous delirium after anesthesia
• Current use of drug or alcohol on the day of surgery
• Currently on medications inhibiting cytochrome P450
• Failed anesthesia clearance
• Reported anxiety or a history of anxiolytic use
• Vitreoretinal surgery performed within the last 3 months of the current procedure
• Impaired renal or liver function