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Photoaging is a common concern within the cosmeceutical industry with many products that are available. One frequently used product is hydroquinone that is used to even skin tone. However, hydroquinone has several shortcomings. The ingredient is controversial for its potential safety issues and it has been banned in Europe. An alternative ingredient that has emerged for its potential use is hexyresorcinol for evening skin tone. Additionally, hexylresorcinol may have other photoaging benefits such as the reduction in the appearance of fine lines.
Therefore, the aim of this study is to assess how hexyresorcinol may compare to the use of hydroquinone in the setting of photoaging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Comparator | Experimental | Emulsion containing 1% Hexylresourcinol |
|
| Intervention | Active Comparator | Emulsion containing 2% Hydroquinone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hexylresourcinol | Other | Emulsion containing hexylresorcinol as an active |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the use of topical hexylresorcinol versus hydroquinone skin regimen on the objective appearance of skin photoaging - specifically appearance of pigment. | Assessed Through Skin Colorimeter (Validated Measurement Tool) - by melanin measurement on cheeks, hands, and face. | 12 weeks |
| To assess the use of topical hexylresorcinol versus hydroquinone skin regimen on the clinical grading of appearance of skin photoaging - specifically appearance of pigment. | Pigment was assessed through clinical grading of 0 (none) to 3 (severe) scale by board-certified dermatologist of each side of the face. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Observe and assess changes in the appearance of skin redness | Assessed using skin colorimeter (validated measurement tool) - by erythema measurement | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective Tolerability Assessment | Assessed through subjective questionnaire | Assessed at Week 4, 8, and 12 |
Inclusion Criteria:
Exclusion Criteria:
• Individuals who have been on any medication that has caused a change in skin pigmentation based on the opinion of the investigator
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| Name | Affiliation | Role |
|---|---|---|
| Raja Sivamani, MD | Pacific Skin Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Integrative skin Science and Research | Sacramento | California | 95815 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36502500 | Derived | Wu H, Gabriel TA, Burney WA, Chambers CJ, Pan A, Sivamani RK. Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance. Arch Dermatol Res. 2023 Jul;315(5):1207-1214. doi: 10.1007/s00403-022-02514-0. Epub 2022 Dec 11. |
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Data will be published in a scientific journal with raw data made available to researchers upon request.
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| ID | Term |
|---|---|
| C031927 | hydroquinone |
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| Hydroquinone |
| Other |
Emulsions containing hydroquinone as an active |
|