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Necrotizing enterocolitis (NEC) is a gastrointestinal system disease characterized by inflammatory necrosis of the intestine mainly seen in premature infants, and continues to be an important cause of mortality and morbidity in neonatal intensive care units all over the world. Although it is more common in premature infants, it is also seen in term babies when the intestine is ischemic. Although the major problem in premature babies is the immaturity of the intestine, many factors contributing to immaturity play a role in the pathogenesis of NEC.
Necrotizing enterocolitis (NEC) is a gastrointestinal system disease characterized by inflammatory necrosis of the intestine mainly seen in premature infants, and continues to be an important cause of mortality and morbidity in neonatal intensive care units all over the world. Although it is more common in premature infants, it is also seen in term babies when the intestine is ischemic. Although the major problem in premature babies is the immaturity of the intestine, many factors contributing to immaturity play a role in the pathogenesis of NEC.
With this study project, which is planned as a national multicenter prospective study, the incidence of necrotizing enterocolitis in newborn infants born in neonatal intensive care units in our country and the risk factors associated with the NEC, especially the detailed feeding history of the patient (when the first feeding is nourished, antibiotics and other treatments that are being used). Most epidemiological data such as the most common stage of the disease, treatment, prognosis, comparison with the data of other countries will provide important information for the neonatal health of our country.
The aim of this study was to determine the factors affecting the emergence of NEC in neonatal intensive care units and to determine the frequency of NEC.
Study Hypothesis: Delayed enteral feeding, intensive use of antibiotics and nutrients other than breast milk increase the incidence of necrotizing enterocolitis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the incidence, risk factors, treatment, prognosis of necrotizing enterocolitis in newborn infants born in newborn intensive care units in our country | Other | With this project, which is planned as a national multicenter prospective study, the incidence of necrotizing enterocolitis in newborn infants born in newborn intensive care units in our country and the risk factors associated with the disease, especially the detailed feeding history of the patient (when the first feeding is nourished, antibiotics and other treatments that are being used). Most epidemiological data such as the most common stage of the disease, treatment, prognosis, comparison with the data of other countries will provide important information for the neonatal health of our country. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Necrotizing Enterocolitis | Incidence: frequency of NEC during study period | 1 year |
| Risk factors for mild and severe necrotizing enterocolitis | erytrocyte/FFP/trombocyte transfusions,PDA closing therapy, umbilical artery catheterisation, | 1 year |
| Initiation of enteral feeding time, choice of breastfeeding or formula | nutrition: breastfeeding of formula, delayed enteral feeding | 1 year |
| Meconium discharge time | meconium discharge time (hour) | 1 year |
| probiotic usage | probiotic usage, type of probiotic preparation | 1 year |
| severity of necrotizing enrerocolitis | Grade of NEC disease according to modified Bell Criteria | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Prognosis | complications: intestinal perforation, requirement of surgery, short bowell syndrome), mortality rate. | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Newborns diagnosed with NEC in neonatal intensive care units.
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| Name | Affiliation | Role |
|---|---|---|
| Tolga H Çelik, MD | Hacettepe University Faculty of Medicine Department of Pediatrics | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tolga Hasan Çelik, MD | Ankara | 06100 | Turkey (Türkiye) | |||
| Tolga Hasan Çelik |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24751635 | Result | Neu J. Necrotizing enterocolitis. World Rev Nutr Diet. 2014;110:253-63. doi: 10.1159/000358474. Epub 2014 Apr 11. | |
| 25854935 | Result | Lim JC, Golden JM, Ford HR. Pathogenesis of neonatal necrotizing enterocolitis. Pediatr Surg Int. 2015 Jun;31(6):509-18. doi: 10.1007/s00383-015-3697-9. Epub 2015 Apr 9. |
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This study project is planned as a national multi-center study. This study will be carried out through a Web Based Multicenter Work System, which was formed by the Turkish Neonatal Society.
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| Ankara |
| 06100 |
| Turkey (Türkiye) |
| 24652270 | Result | Kasivajjula H, Maheshwari A. Pathophysiology and current management of necrotizing enterocolitis. Indian J Pediatr. 2014 May;81(5):489-97. doi: 10.1007/s12098-014-1388-5. Epub 2014 Mar 22. |
| 25268636 | Result | Niemarkt HJ, de Meij TG, van de Velde ME, van der Schee MP, van Goudoever JB, Kramer BW, Andriessen P, de Boer NK. Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota. Inflamm Bowel Dis. 2015 Feb;21(2):436-44. doi: 10.1097/MIB.0000000000000184. |
| ID | Term |
|---|---|
| D020345 | Enterocolitis, Necrotizing |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D004760 | Enterocolitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D012307 | Risk Factors |
| D013812 | Therapeutics |
| D007363 | Intensive Care Units, Neonatal |
| ID | Term |
|---|---|
| D012306 | Risk |
| D011336 | Probability |
| D013223 | Statistics as Topic |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D015984 | Causality |
| D015981 | Epidemiologic Factors |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D017531 | Health Care Evaluation Mechanisms |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D015278 | Intensive Care Units, Pediatric |
| D007362 | Intensive Care Units |
| D006757 | Hospital Units |
| D006268 | Health Facilities |
| D005159 | Health Care Facilities Workforce and Services |
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