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Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear. Among them, acral manifestation resembling to chilblains appears frequent and quite specific. The aim of this project is to better characterize the cutaneous manifestations occurring during Covid-19 infection with a special focus on chilblains. These acral manifestation could be due to a direct viral effect, but also to microthrombosis or vascularitis. Understanding the pathomechanisms involved could provide interesting clue for understanding not only the skin manifestations but also some of the other systemic symptoms associated to covid-19 infection. This study plan to characterize these acral manifestations by analyzing the clinical and dermoscopic patterns and to correlate them with the non-invasive vascular explorations but also immune and coagulopathy explorations that are done in the CHU of Nice in covid-19 patients.
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| Measure | Description | Time Frame |
|---|---|---|
| Clinical skin manifestations | Type and description of the skin manifestations with a special focus on patients with chilblains | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Histology and biological data | Data on Histology (HE staining and immunofluorescence) and on biology (blood cells counts, CRP and immune profile) will be collected in covid patient with skin manifestation | 3 months |
| Non invasive vascular examination |
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Inclusion Criteria:
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All patients with covid infection presenting with skin manifestations
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cynthia CAILLON | Contact | +33492034011 | caillon.c@chu-nice.fr | |
| Sylvie MALERBA | Contact | +33492034011 | malerba.s@chu-nice.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nice | Recruiting | Nice | 06200 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33237291 | Derived | Hubiche T, Cardot-Leccia N, Le Duff F, Seitz-Polski B, Giordana P, Chiaverini C, Giordanengo V, Gonfrier G, Raimondi V, Bausset O, Adjtoutah Z, Garnier M, Burel-Vandenbos F, Dadone-Montaudie B, Fassbender V, Palladini A, Courjon J, Mondain V, Contenti J, Dellamonica J, Leftheriotis G, Passeron T. Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic. JAMA Dermatol. 2021 Feb 1;157(2):202-206. doi: 10.1001/jamadermatol.2020.4324. |
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| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D002647 | Chilblains |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005627 | Frostbite |
| D000067390 | Cold Injury |
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Serum, skin biopsy, urine
Vascular examination will be performed by Capillaroscopy, laser-doppler or lung TDM if clinically required
| 3 months |
| D014947 | Wounds and Injuries |