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| Name | Class |
|---|---|
| Sprim Advanced Life Sciences | OTHER |
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The study is a single center, open label, nutrition intervention study. Healthy adult male working at a Singapore construction site are included if they fulfill inclusion and exclusion criteria. Volunteers receive fortified rice for their daily lunch and dinner each day of the week (i e 14 meals/week) over six months. Nutrition status in blood is measured at baseline and after six months of fortified rice consumption.
The study is a single center, open label, uncontrolled longitudinal nutrition intervention study. Migrant construction workers of either Bangladeshi or Indian ethnicity from a single dormitory in Singapore volunteer to participate at the study. Only eligible workers are included in the study if they fulfilled all inclusion and exclusion criteria; 20 and 51 years old, a BMI between 17.0 to 27.5 kg/m2, willing to adhere to the study procedure for at least six months, and sign informed consent, are free of current medical and/or chronic/non communicable diseases, no history of heavy smoking or alcohol consumption. The eligible subjects receive fortified rice for their daily lunch and dinner each day of the week (i e 14 meals/week) over six months. The nutrient levels per 100 g fortified rice contain 150 µg vitamin A (Vitamin A palmitate), 0.5 mg vitamin B1 (thiamin mononitrate), 7 mg vitamin B3 (niacin amide), 0.6 mg vitamin B6 (pyridoxine hydrochloride), 1 µg vitamin B12 (cyanocobalamin), 130 µg folic acid, 4 mg iron (ferric pyrosphosphate), and 6 mg zinc (zinc oxide). At baseline and after 6 months of intervention, BMI and vital signs such as blood pressure, pulse and body temperature are collected. Also, 10 ml venous blood is sampled at baseline and after 6 months of intervention and subsequently tested for hemoglobin, serum folate, and serum zinc, serum ferritin and serum vitamin B12 status. In a small subset of the migrant construction workers, an extra 5 ml blood sample is taken for homocysteine testing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fortified rice | Experimental | fortified rice for daily lunch and dinner each day of the week (i.e. 14 meals/week) for six months |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fortified rice | Other | 100 g of rice was fortified with 150 µg vitamin A (Vitamin A palmitate), 0.5 mg vitamin B1 (thiamin mononitrate), 7 mg vitamin B3 (niacin amide), 0.6 mg vitamin B6 (pyrodoxine hydrochloride), 1 µg vitamin B12 (cyanocobalamin), 130 µg folic acid, 4 mg iron (ferric pyrosphosphate), and 6 mg zinc (zinc oxide). |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoglobin status | Hemoglobin concentration in blood | From baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Folate status | Red blood cell folate concentration in serum | From baseline to 6 months |
| Zinc status | Serum zinc concentration | From baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Height | Height (cm) | From baseline to 6 months |
| Weight | Weight (kg) | From baseline to 6 months |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SPRIM | Singapore | 118264 | Singapore |
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| Iron status | Serum ferritin concentration | From baseline to 6 months |
| Vitamin B12 status | Serum vitamin B12 concentration | From baseline to 6 months |
| Homocysteine status | Serum homocysteine concentration | From baseline to 6 months |
| BMI | BMI calculated from height and weight | From baseline to 6 months |
| Blood pressure | Systolic and Diastolic Blood Pressure (mmHg) | From baseline to 6 months |
| Pulse | Pulse (count/min) | From baseline to 6 months |
| Body temperature | Body temperature (degrees Celsius) | From baseline to 6 months |