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| Name | Class |
|---|---|
| University Hospital, Bordeaux | OTHER |
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Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parent of patient with cryptorchidism | parent exposition of endocrine disruptors |
| |
| Parent of patient without cryptorchidism | Parent exposition of endocrine disruptors |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors | Other | Measure of the exposure of parent of patient with/without cryptorchidism to endocrine disruptors (job exposure, during pregnancy) |
| Measure | Description | Time Frame |
|---|---|---|
| frequency of the job exposure of the parents of endocrine disruptors | Measure of the frequency of endocrine disruptors assessed by european questionary QLK4-1999-01422 (simplified version ) | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| comparison of cryptorchid and non-cryptorchid children born to parents with isolated exposure vs multiple exposures | Assessement by the Job-exposure matrix EDC (Environment disrupting chemicals) | 1 day |
| Comparison of frequencies of exposure to endocrine disruptors (Environmental Disrupting Chemicals) in parents giving birth to a congenital cryptorchid child vs child not cryptorchid at birth but with secondary cryptorchidism. |
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Inclusion criteria:
- Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism
Exclusion criteria:
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Parent of patient with cryptorchidism
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicolas KALFA, MD | Contact | 00334 67 33 87 84 | n-kalfa@chu-montpellier.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital of Montpellier | Recruiting | Montpellier | 34295 | France |
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| ID | Term |
|---|---|
| D003456 | Cryptorchidism |
| ID | Term |
|---|---|
| D013733 | Testicular Diseases |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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presence of cryptorchidism at birth or secondarily |
| 1 day |
| identify food exposure criteria (phytoestrogen or EDC pesticides) associated with the presence of a cryptorchid. | parents will be asked about their diet | 1 day |
| Constitution of collection of biological samples from children with non-palpable bilateral cryptorchidism | The aim is only to make a collection of blood samples. Anonymous samples will be used later in order to improve knowledge of the cryptorchidism. | 1 day |
| D052801 |
| Male Urogenital Diseases |
| D014564 | Urogenital Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |