A Phase I, Open-Label study designed to assess the pharmacokinetics (PK), safety and tolerability of ipatasertib in Chinese participants. Approximately 20 Chinese participants (12 PK-evaluable participants) with locally advanced or metastatic solid tumors for whom standard therapy either does not exist or has proven ineffective will be enrolled to provide sufficient data. Participants will receive a 400-mg ipatasertib dose (two 200-mg tablets) daily orally (PO). Participants deriving clinical benefit may be offered continued treatment with ipatasertib until disease progression, at the discretion of the investigator (as assessed by the investigator) or until the study is terminated by the Sponsor.

Inclusion Criteria:

• Histologically documented locally advanced or metastatic solid tumor that has progressed or failed to respond to at least one prior regimen.
• Not a candidate for regimens known to provide clinical benefit.
• Evaluable or measurable disease according to RECIST, v1.1.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at screening.
• Life expectancy of >= 12 weeks.
• Adequate haematologic and organ function within 14 days prior to initiation of study treatment.
• Women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures and agreement to refrain from donating eggs.
• Men: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures, and agreement to refrain from donating sperm.
• Participants must reside in the People's Republic of China

Exclusion Criteria:

• Leptomeningeal disease as the only manifestation of the current tumor.
• Type 1 or 2 diabetes mellitus requiring insulin at study entry.
• Inability or unwillingness to swallow pills.
• Malabsorption syndrome or other condition that would interfere with enteral absorption.
• Known and untreated, or active CNS metastases (progressing or requiring anticonvulsants for symptomatic control).
• Congenital long QT syndrome or corrected QT interval (QTc) > 480 ms.
• Active congestive heart failure or ventricular arrhythmia requiring medication.
• Uncontrolled pleural effusion, pericardial effusion, or ascites requiring weekly paracentesis for 3 consecutive weeks prior to initiation of ipatasertib treatment.
• Severe infections within 4 weeks prior to screening including but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia.
• Requirement for any daily supplemental oxygen.
• History of Inflammatory bowel disease or active bowel inflammation.
• Symptomatic hypercalcemia requiring continued use of bisphosphonate or denosumab therapy.
• Clinically significant history of liver disease, including viral disease or hepatitis,current alcohol abuse or cirrhosis.
• Known HIV infection.
• Active (chronic or acute) hepatitis C virus (HCV) at screening.
• Hepatitis B virus (HBV) infection (chronic or acute), defined as having a positive hepatitis B surface antigen (HBsAg) test or a positive quantitative HBV DNA test at screening
• Significant traumatic injury within 3 weeks prior to initiation of ipatasertib treatment.
• Major surgical procedure within 4 weeks prior to initiation of ipatasertib treatment.
• Treatment with chemotherapy, immunotherapy, or biologic therapy as cancer therapy within 3 weeks prior to initiation of ipatasertib treatment.
• Use of strong CYP3A4 inhibitors within 4 weeks prior to initiation of ipatasertib treatment.
• Oral endocrine therapy within 2 weeks prior to initiation of ipatasertib treatment.
• Prior treatment with a PI3-kinase inhibitor in which the patient experienced a Grade >= 3 drug-related adverse event or otherwise would be at increased risk for additional PI3K-related toxicity.
• Palliative radiation to bony metastases within 2 weeks prior to initiation of ipatasertib treatment.
• Radiotherapy (other than palliative radiation to bony metastases) as cancer therapy within 4 weeks prior to initiation of ipatasertib treatment.
• Treatment with an investigational agent within 4 weeks prior to initiation of ipatasertib treatment.
• Unresolved toxicity from prior therapy, except for alopecia and Grade 1 peripheral neuropathy.
• Pregnant or lactating.
• Inability to comply with study and follow-up procedures.

Qualified researchers may request access to individual patient level data through the clinical study data request platform (www.clinicalstudydatarequest.com). Further details on Roche's criteria for eligible studies are available here (https://clinicalstudydatarequest.com/Study-Sponsors/Study-Sponsors-Roche.aspx). For further details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (https://www.roche.com/research\_and\_development/who\_we\_are\_how\_we\_work/clinical\_trials/our\_commitment\_to\_data\_sharing.htm).