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The current study will be conducted to evaluate the effectiveness of matrix metalloproteinases inhibitors on erosive oral lichen planus.
Matrix metalloproteinases inhibitor (Orochem) will be given to patients with Oral erosive lichen planus three times daily for 3 weeks. Then the subjective discomfort and pain severity as well as the objective disease severity scores will be collected.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Orochem (Test) | Experimental | fifteen patients with lichen planus will be treated with MMPs neutralizing agent 3 times daily for 3 weeks. then pain, discomfort and disease severity will be assessed at 1 and 3 weeks periods. |
|
| Conventional (Control) | Active Comparator | fifteen patients with oral lichen planus confirmed with a biopsy will be treated with topical corticosteroids, topical antifungal 3 timed daily for 3 weeks. then pain, discomfort and disease severity will be assessed at 1 and 3 weeks periods. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Matrix Metalloproteinase Inhibitors (Orochem) | Drug | topical application of MMP inhibitors for 3 weeks to evaluate its effectiveness in treating oral lichen planus |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in disease severity score | Thongprasom disease severity score (5-0) | change in disease severity score from baseline to 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hossam H. AlSabbagh, As. lecturer | Alexandria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| periodontology department, Faculty of dentistry, Alexandria University | Alexandria | 21500 | Egypt |
participants data are not to be shared
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| ID | Term |
|---|---|
| D017676 | Lichen Planus, Oral |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D008010 | Lichen Planus |
| D017512 | Lichenoid Eruptions |
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| ID | Term |
|---|---|
| D061965 | Matrix Metalloproteinase Inhibitors |
| D014222 | Triamcinolone Acetonide |
| ID | Term |
|---|---|
| D011480 | Protease Inhibitors |
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
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double equal arms
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participant, investigator as well as outcome assessor are blinded
| Kenacort A, | Drug | topical application of both drugs 3 times daily for 3 weeks as an active control |
|
|
| D017444 |
| Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D020164 | Chemical Actions and Uses |
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |