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| Name | Class |
|---|---|
| University of Cambridge | OTHER |
| Lundbeck Foundation | OTHER |
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The aim of this project is to investigate:
Previous studies have shown that 5-HT is strongly implicated in compulsive behaviours in experimental animals. Manipulation of 5-HT influences neuronal interactions underlying action selection. Reduced forebrain 5-HT causes perseveration and impairs goal-directed behaviour under reward but not punishment. Dysfunctional 5-HT neurotransmission has also been implicated in Obsessive-Compulsive Disorder (OCD) based on the selective efficacy of relatively high doses of selective serotonin reuptake inhibitors (SSRIs) in treating this disorder. Hitherto, it is unknown whether there is a primary defect in the serotonergic system or whether SSRIs ameliorate symptoms by modulating other brain neurotransmitter pathways. So far, only one study of central 5-HT release in OCD patients has been conducted and its methodology may be questioned.
A number of behavioural and cognitive features of OCD, including endophenotype markers that appear to characterise the disorder have been determined. These include a shift in cognitive control from a goal-directed strategy to a habitual (stimulus-response, S-R) strategy, cognitive rigidity in terms of both reversal learning and attentional set-shifting, impaired response inhibition and planning, and a tendency to over-respond to spurious negative feedback in a probabilistic learning paradigm. Neural substrates of these deficits are being investigated using brain imaging methodologies based on magnetic resonance and preliminary evidence suggests an over-active medial prefrontal cortex-caudate nucleus circuits and underactive lateral prefrontal cortex-putamen circuits. However, little evidence exists that relates to the hypothesis of an over-active habit system in this disorder or to the role of serotonin in all these cognitive and behavioural deficits observed in OCD and compulsivity in general.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Control Group | Placebo Comparator | The healthy placebo control group will be administered the exact same procedure as the intervention group, the only difference being that this group will be administered a placebo tablet. |
|
| Obsessive-Compulsive Disorder / High Compulsivity Control Group | Placebo Comparator | The OCD/high compulsivity placebo control group will be administered the exact same procedure as the intervention group, the only difference being that this group will be administered a placebo tablet. |
|
| Healthy Intervention Group | Experimental | The healthy intervention group will be administered 20mg of Escitalopram daily for 3-4 weeks. |
|
| Obsessive-Compulsive Disorder / High Compulsivity Intervention Group | Experimental | The OCD/high compulsivity intervention group will be administered 20mg of Escitalopram daily for 3-4 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Escitalopram | Drug | 20mg daily for 3-4 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Learning Primary Outcome 1 measured with Probability Reversal Learning test: Mean errors Stage 1 (Learning) | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 years |
| Learning Primary Outcome 2 measured with Probability Reversal Learning test: Mean errors Stage 2 (Reversal) | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Primary Outcome 3 measured with Deterministic Reversal Learning test: Percent correct per stage | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Inhibition Primary Outcome 1 measured with Interleaved Stop Signal Task/Go-NoGo: Stop Signal Reaction Time | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Flexibility Primary Outcome 1 measured with 3Dimensional Intra/Extra Dimensional Shift test: Extra Dimensional Set Errors | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Flexibility Primary Outcome 2 measured with Sequential model-based model-free test: Model-based Model-free Weight |
| Measure | Description | Time Frame |
|---|---|---|
| Learning Secondary Outcome 1 measured with Probability Reversal Learning test: Stage 1 Reward-Stay/Lose-Shift behaviour | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Measure | Description | Time Frame |
|---|---|---|
| Emotion Recognition Other Outcome 1: Detection threshold decreasing Happy - Intensity Morphing | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 2: Detection threshold decreasing Sad - Intensity Morphing |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gitte M. Knudsen, Professor | Neurobiology Research Unit, Rigshospitalet | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neurobiology Research Unit, Rigshospitalet | Copenhagen | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15131308 | Background | Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC. Cognitive inflexibility after prefrontal serotonin depletion. Science. 2004 May 7;304(5672):878-80. doi: 10.1126/science.1094987. | |
| 19400722 | Background | Dayan P, Huys QJ. Serotonin in affective control. Annu Rev Neurosci. 2009;32:95-126. doi: 10.1146/annurev.neuro.051508.135607. |
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Upon completion of the study all data will be uploaded to the existing Center for Integrated Molecular Brain Imaging (CIMBI) Database. Researchers may apply for access to the data.
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Upon completion of the study.
Researchers may apply for access to the data.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| SAP | No | Yes | No | Statistical Analysis Plan | Jul 8, 2024 | Jul 9, 2024 | SAP_000.pdf |
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| ID | Term |
|---|---|
| D000089983 | Escitalopram |
| ID | Term |
|---|---|
| D011437 | Propylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009570 | Nitriles |
| D001572 |
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| Placebo oral tablet | Drug | 20mg placebo tablet daily for 3-4 weeks. |
|
|
Outcome variables have been grouped a priori into carefully defined cognitive domains. |
| 3 Years |
| Social Cognition Primary Outcome 1 measured with EMOTICOM Moral Emotions Task: Agent Guilt Score | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Social Cognition Primary Outcome 2 measured with EMOTICOM Moral Emotions Task: Agent Shame Score | Outcome variables have been grouped a priori into carefully defined cognitive domains. The false discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Primary Outcome 1 measures with EMOTICOM Intensity Morphing: Affective bias in decreasing condition | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Primary Outcome 2 measured with EMOTICOM Emotion Recognition Task: Affective bias for D' | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Primary Outcome 3 measured with EMOTICOM Intensity Morphing task: Detection threshold decreasing | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Primary Outcome 4 measured with EMOTICOM Emotion Recognition task: D'Prime for emotion recognition | Emotion Recognition Task. Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Memory Primary Outcome 1 measured with CANTAB Paired Associates Learning: Total Errors Adj | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Biofluids | Serum Escitalopram levels | 3 Years |
| Positron emission tomography (PET) Imaging: Cerebral [11C]SB207145 PET binding. | Collected before and after participant's intervention. | 3 Years |
| Neural Activations and Correlations measured with functional magnetic resonance imaging (fMRI) paradigm named Slip of Actions | Imaging outcomes will be Family-Wise Error (FWE) corrected using Random Field Theory as implemented in SPM12. | 3 Years |
| Neural Activations and Correlations measured with functional magnetic resonance imaging (fMRI) paradigm named Cohabit | Imaging outcomes will be Family-Wise Error (FWE) corrected using Random Field Theory as implemented in SPM12Co-habit fMRI paradigm Imaging outcomes will be FWE corrected using Random Field Theory as implemented in SPM12. | 3 Years |
| Neural Activations and Correlations measured with functional magnetic resonance imaging (fMRI) paradigm named Faces | Imaging outcomes will be Family-Wise Error (FWE) corrected using Random Field Theory as implemented in SPM12. | 3 Years |
| Resting State fMRI | Imaging outcomes will be Family-Wise Error (FWE) corrected using Random Field Theory as implemented in SPM12. | 3 Years |
| Structural Voxel-based morphometry (VBM) MRI | Imaging outcomes will be Family-Wise Error (FWE) corrected using Random Field Theory as implemented in SPM12. | 3 Years |
| Diffusion Tensor Imaging MRI | 3 Years |
| Habit formation outcome 1: response times for each day of training | Daily app training paradigm | 3 Years |
| Habit formation outcome 2: mean errors per sequence and moves | Daily app training paradigm | 3 Years |
| Habit formation outcome 3: confidence and enjoyable rates. | Daily app training paradigm | 3 Years |
| Learning Secondary Outcome 2 measured with Probability Reversal Learning test: Stage 1 Reward/Punishment learning | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Secondary Outcome 3 measured with Probability Reversal Learning test: Stage 1. Stimulus Stickiness | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Secondary Outcome 4 measured with Probability Reversal Learning test: Stage 2 Reward-Stay/ Lose-Shift behaviour | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Secondary Outcome 5 measured with Probability Reversal Learning test: Stage 2 Reward/Punishment learning | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Secondary Outcome 6 measured with Probability Reversal Learning test: Stage 2. Stimulus Stickiness | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Learning Secondary Outcome 7 measured with Deterministic Reversal Learning test: Reward-Stay/ Lose-Shift behaviour | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 1 measured with Sequential Model-Based/Model-Free test: Proportion of Stays | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 2 measured with Sequential Model-Based/Model-Free test: Exploration | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 3 measured with Sequential Model-Based/Model-Free test: Stimulus Stickiness | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 4 measured with Sequential Model-Based/Model-Free test: Learning rate | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 5 measured with 3Dimensional Intra/Extra Dimensional Shift test: Pre Extra Dimension Set Errors | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Flexibility Secondary Outcome 6 measured with 3Dimensional Intra/Extra Dimensional Shift test: Latency | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Inhibition Secondary Outcome 1 measured with Interleaved Stop Signal Task/Go-NoGo: Go reaction time | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Inhibition Secondary Outcome 2 measured with Interleaved Stop Signal Task/Go-NoGo: Go omission error rate | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Inhibition Secondary Outcome 3 measured with Interleaved Stop Signal Task/Go-NoGo: Go commission error rate | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Inhibition Secondary Outcome 4 measured with Interleaved Stop Signal Task/Go-NoGo: No-Go error rate | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Executive Function Secondary Outcome 1 measured with 3Dimensional Intra/Extra Dimensional Shift test: Total Errors Adjusted | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Secondary Outcome 1 measured with EMOTICOM Intensity Morphing Task: Detection threshold increasing | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Secondary Outcome 2 measured with EMOTICOM Intensity Morphing Task: Affective bias in increasing condition | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Secondary Outcome 3 measured with EMOTICOM Emotion Recognition Task: Affective bias for Hit Rate | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Emotion Recognition Secondary Outcome 4 measured with EMOTICOM Emotion Recognition Task.: Hit Rate for Emotion Recognition | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Faces and geometric figure discrimination Outcome 1 measured with fMRI faces paradigm: Accuracy | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Behavioural outcomes with Faces and geometric figure discrimination Outcome 2 measured with fMRI faces paradigm: Response Speed | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Behavioural outcomes with fMRI paradigm slip of Actions : accuracy and latency | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Behavioural outcomes with fMRI paradigm Co-habit: accuracy and latency. | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Memory Outcome 1 measured with CANTAB Paired Associates Learning test: First Trial Memory Score | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Memory Outcome 2 measured with Letter-number sequencing test: Total score | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Memory Primary outcome 3 measured with Verbal Affective Memory Test-26: Latent variable model of the association between positive, negative and neutral word recall and 5-HT4R binding | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Risky Decision Making Outcome Outcome 1 measured with EMOTICOM Cambridge Gamble Task: Quality of Decision Making | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Risky Decision Making Outcome 2 measured with EMOTICOM Cambridge Gamble Task: Risk Adjustment | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Risky Decision Making Outcome 3 measured with EMOTICOM Cambridge Gamble Task: Overall Proportion Bet | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Risky Decision Making Outcome 4 measured with EMOTICOM Cambridge Gamble Task: Deliberation Time | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Psychomotor Speed Outcome 1 measured with CANTAB Reaction Time Task: Simple reaction time | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain. | 3 Years |
| Intelligence Quotient (IQ) outcome 1 measured with Reynolds Intellectual assessment Scales subtest "guess what" and "what does not fit": Total age adjusted score | Outcome variables have been grouped a priori into carefully defined cognitive domains. False discovery rate (FDR) correction, for multiple comparisons, using the Benjamini-Hochberg procedure will be applied to the outcomes within each cognitive domain | 3 Years |
| Interpersonal Reactivity Index (IRI) Score | 3 Years |
| Obsessive- Compulsive Inventory (OCI)- state Score | 3 Years |
| Obsessive- Compulsive Inventory- trait Score | 3 Years |
| Brief Symptom Inventory (BSI) Score | 3 Years |
| Pittsburgh Sleep Quality Index Score | 3 Years |
| Profile of Mood State Score | 3 Years |
| Beck Depression Inventory-II Score | Contain 21-items, scored on a scale value of 0 to 3 | 3 Years |
| State-Trait Anxiety Inventory Scale Score | Contain 40-items | 3 Years |
| State and Trait Aggression Questionnaire Score | 3 Years |
| Barratt Impulsiveness Scale-State Score | 3 Years |
| Visual Analogue Scale Score | 3 Years |
Outcome variables have been grouped a priori into carefully defined cognitive domains. |
| 3 Years |
| Emotion Recognition Other Outcome 3: Detection threshold decreasing Anger - Intensity Morphing | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 4: Detection threshold decreasing Fear - Intensity Morphing | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 5: Detection threshold decreasing Disgust - Intensity Morphing | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 6: D' Happy - Emotion Recognition Task | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 7: D' Sad - Emotion Recognition Task | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 8: D' Fear - Emotion Recognition Task | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Emotion Recognition Other Outcome 9: D' Anger - Emotion Recognition Task | Outcome variables have been grouped a priori into carefully defined cognitive domains. | 3 Years |
| Activity Level Score | 3 Years |
| Behavioural Inhibition/ Behavioural Avoidance Scale Score | 3 Years |
| The Compulsive Personality Assessment Scale Score | 3 Years |
| Sexuality Questionnaire Score | 3 Years |
| Edinburgh Handedness Inventory Score | 3 Years |
| Revised NEO Personality Questionnaire Score | 3 Years |
| Family History Assessment Module Score | 3 Years |
| Positive Life Events Score | 3 Years |
| Stressful Life Events Score | 3 Years |
| Perceived stress scale | 3 Years |
| Barratt Impulsiveness Scale-Trait Score | 3 Years |
| The Penn State Worry Questionnaire- Trait Score | 3 Years |
| The Penn State Worry Questionnaire- State Score | 3 Years |
| The Self-Control Scale- Trait Score | 3 Years |
| The Self-Control Scale- State Score | 3 Years |
| State- Trait Anxiety Inventory- Trait Score | 3 Years |
| The Warwick-Edinburgh Mental Well-being Scale -State Score | 3 Years |
| The Warwick-Edinburgh Mental Well-being Scale -Trait Score | 3 Years |
| Mindful Attention and Awareness Scale -State Score | 3 Years |
| Mindful Attention and Awareness Scale -Trait Score | 3 Years |
| The Intolerance of Uncertainty Scale - Trait Score | 3 Years |
| The Intolerance of Uncertainty Scale - State Score | 3 Years |
| Verran and Snyder-Halpern (VSH) Sleep Scale Score | 3 Years |
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| 25567322 | Background | Banca P, Voon V, Vestergaard MD, Philipiak G, Almeida I, Pocinho F, Relvas J, Castelo-Branco M. Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder. Brain. 2015 Mar;138(Pt 3):798-811. doi: 10.1093/brain/awu379. Epub 2015 Jan 6. |
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| Background | Foa, E. B. et al. The validation of a new obsessive-compulsive disorder scale: The obsessive-compulsive inventory. Psychological Assessment 10(3), 206-214, 1998. |
| Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |