Not provided
Not provided
Not provided
Not provided
Not provided
The study has been terminated due to the pandemic.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water | No Intervention | 250 ml of water mixed with 1g of citric acid. | |
| Sugar | Active Comparator | 65g of sugar dissolved in 250ml of water |
|
| Stevia | Experimental | 5g of stevia dissolved in 250ml of water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sugar replacements | Other | Participants will receive a solution of stevia before being administered a fixed meal (lunch). Glucose and insulin levels, and Visual analogue scale data will be collected. |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial glucose levels | Change in glucose levels two hours after the administration of a fixed meal | Capillary blood glucose will be measured two hours after the administration of a fixed meal. |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial insulin levels | Change in postprandial insulin levels two hours after the administration of a fixed meal | Postprandial insulin levels will be measured two hours of the administration of a fixed meal |
| Area under the curve (AUC) for glucose |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Farzad Amirabdollahian, PhD | Liverpool Hope University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Health sciences, Liverpool Hope University | Liverpool | L16 9JD | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31842388 | Background | Farhat G, Berset V, Moore L. Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial. Nutrients. 2019 Dec 12;11(12):3036. doi: 10.3390/nu11123036. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
Not provided
Not provided
Not provided
Not provided
Not provided
Single (participant)
Changes in AUC for glucose throughout the intervention |
| Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch |
| Subjective feelings of satiety | Visual analogue scales | VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |