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| Name | Class |
|---|---|
| Tumorzentrum Regensburg, Institut für Qualitätssicherung und Versorgungsforschung, Universität Regensburg | UNKNOWN |
| Arbeitsgemeinschaft Deutscher Tumorzenten e.V., ADT | UNKNOWN |
| Wissenschaftliches Institut der AOK (WIdO) |
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Assessment of the effectiveness of care in certified cancer centres for eight cancer entities via a retrospective cohort study based on secondary data from statutory health insurance funds and population-based clinical cancer registries.
Cancer constitutes the second most frequent cause of death in Germany. To maintain a high quality of treatment, the national cancer plan aims at a unified certification of cancer centres.
The project "Wirksamkeit der Versorgung in onkologischen Zentren" (WiZen) investigates effects of treatments in certified cancer centres across large populations and different cancer entities in comparison to hospitals that do not hold a certificate.
WiZen is a retrospective comparative cohort study that analyzes incident cases of eight types of cancer diagnosed within 2009-2017 based on nationwide health insurance data provided by WIdO (the AOK research institute) and data from regional clinical cancer registries (CCR) for the period 2006-2017. These eight types of cancer are colorectal cancer, pancreatic cancer, breast cancer, gynecologic tumors, lung cancer, prostate cancer, head and neck tumors and neuro-oncological tumors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Cancer patients who have undergone substantial parts of inpatient treatment in a certified cancer centre. |
| |
| Control | Cancer patients who have not undergone inpatient treatment in a certified cancer centre. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oncological certification | Other | Oncological certification encompasses a variety of criteria such as treatment according to the clinical guidelines, staffing, technical infrastructure, minimum caseloads, and multidisciplinary care. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Survival after first hospitalization due to cancer | first hospitalization (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]), up to 31/12/2017 |
| 1- and 5-year survival | 1- and 5-year survival after first hospitalization due to cancer | first hospitalization (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]) with 1 or 5-year follow-up, respectively |
| 30-day mortality | 30-day mortality after first hospitalization due to cancer | first hospitalization (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]) with 30 days follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| 2-, 3-, 4-year survival | 2-, 3-, 4-year survival after first hospitalization due to cancer | first hospitalization (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]) with 2,3, or 4-year follow-up, respectively |
| Recurrence-free survival |
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Inclusion Criteria:
Exclusion Criteria:
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German residents with continuous insurance of one of the AOK funds 2006-2017 and patients recorded in one of the participating cancer registries Dresden, Erfurt, Regensburg and Berlin-Brandenburg 2006-2017
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Technische Universität Dresden | Dresden | Saxony | 01307 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41188998 | Derived | Hansinger J, Schoffer O, Volkel V, Gerken M, Wimberger P, Bierbaum V, Bobeth C, Rossler M, Droge P, Ruhnke T, Gunster C, Kleihues-van Tol K, Link T, Kast K, Papathemelis T, Ortmann O, Schmitt J, Klinkhammer-Schalke M. Comparison of survival in ovarian cancer patients following treatment in certified gynecologic oncology centers and non-certified hospitals: a German retrospective cohort study (WiZen). J Ovarian Res. 2025 Nov 4;18(1):238. doi: 10.1186/s13048-025-01843-8. | |
| 35672675 |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D001943 | Breast Neoplasms |
| D010051 | Ovarian Neoplasms |
| D002583 | Uterine Cervical Neoplasms |
| D016889 | Endometrial Neoplasms |
| D002283 | Carcinoma, Bronchogenic |
| D011471 | Prostatic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D016543 | Central Nervous System Neoplasms |
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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Recurrence-free survival after cancer diagnosis
| cancer diagnosis (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]), up to 31/12/2017 |
| Cumulative recurrence rate | Cumulative recurrence rate after cancer diagnosis | cancer diagnosis (starting from 01/01/2009 [WIdO] or 01/01/2006 [CCR]), up to 31/12/2017 |
| Complications due to surgery | Complications due to cancer surgery | date of initial cancer surgery with entity-specific follow-up |
| Successive resection | Second resection due to cancer | second resection within three months of initial cancer surgery |
| Entity-specific outcomes defined by clinical experts |
| 2009-2017 [CCR] or 2006-2017 [WIdO] |
| Fraction of patients | Fraction of patients in certified centres and in non-certified hospitals over time | 2009-2017 |
| Regional differences | Differences across outcomes in different counties or federal states | 2009-2017 |
| Differences in patient characteristics | Differences in demographic characteristics, disease severity and risk factors across certified centres/non-certified hospitals | 2009-2017 [CCR] or 2006-2017 [WIdO] |
| Pathways of treatment | Patient's treatment pathways among general practitioners, specialists, and hospitals w.r.t. certification | 2009-2017 |
| Severity Levels in insurance data | Deduction of cancer severity levels through linkage of health insurance and cancer registry data | 2009-2017 |
| Derived |
| Roessler M, Schmitt J, Bobeth C, Gerken M, Kleihues-van Tol K, Reissfelder C, Rau BM, Distler M, Piso P, Gunster C, Klinkhammer-Schalke M, Schoffer O, Bierbaum V. Is treatment in certified cancer centers related to better survival in patients with pancreatic cancer? Evidence from a large German cohort study. BMC Cancer. 2022 Jun 7;22(1):621. doi: 10.1186/s12885-022-09731-w. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |
| D014594 | Uterine Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D005834 | Genital Neoplasms, Male |
| D005832 | Genital Diseases, Male |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D009423 | Nervous System Neoplasms |
| D009422 | Nervous System Diseases |
| D010182 | Pancreatic Diseases |