Multi Point Pacing vs. Conventional STUDY PROTOCOL

Observational, Multicentre, Investigator and Patient Blinded, Prospective, Randomized Comparator Study of Cardiac Resynchronization Therapy (CRT) Multi Point Pacing (MPP) Compared to Conventional CRT Pacing Response in Heart Failure Patients.

The Purpose of this study is to compare two programming modalities for CRT devices in Heart Failure patients with an indication for Cardiac Resynchronization Therapy

Inclusion Criteria:

• Patients with indication for CRT (-P or -D) as per ESC guidelines. Ability to provide written informed consent. Optimal Medical Therapy for at least 3 months

Exclusion Criteria:

• < 18 years and younger
• Pregnant or breastfeeding patients
• Non-LBBB patients (RBBB, intra-ventricular delay)
• Non-ambulatory NYHA class IV effort tolerance
• Myocardial infarction within 40 days before enrolment
• Cardiac surgery or revascularization procedure within 3 months before enrolment, or scheduled in the following 6 months
• Atrial Fibrillation (AF) patients unless AV node ablation is performed, or complete AV block is present (to ensure optimal CRT delivery)
• Patients with life expectancy of less than 12 months due to other medical conditions
• Patients who are involved in another investigational study (device or medical)