Brain Stimulation for Patients With Parkinson Disease

Brain Stimulation for Patients With Parkinson Disease

The aim of this crossover study is to investigate the efficacy of non-invasive brain stimulation (transcranial pulse stimulation; TPS) in adults with Parkinson Disease (PD). Participants will receive 6 sessions of TPS and Sham-TPS, respectively, in random order. Motor manifestations of PD and manual dexterity will be the primary outcome measures. Outcomes will be assessed immediately post-treatment.

Inclusion Criteria:

• Clinically stable PD with fine skilled and/or gross motor deficits (e.g. right arm with a clinical force level >2)
• Signed written informed consent
• Monthly pregnancy test for women in childbearing years
• Age >= 18 years

Exclusion Criteria:

• Non-compliance with the protocol
• Pregnant or breastfeeding women
• Relevant intracerebral pathology unrelated to the disease (e.g. Brain tumor)
• Hemophilia or other blood clotting disorders
• Cortisone treatment within the last 6 weeks before first treatment
• Thrombosis