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A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. Gingival crevicular fluid periostin levels were assessed at baseline, at the 6th week and the 3rd month after treatment.
Periostin is commonly found in collagen-rich tissues, which is thought to affect the production of collagen fibers. Additionally, periostin is synthesized in tissues exposed to constant mechanical forces such as the periosteum, periodontal ligament, tendon, heart valve and skin. Periostin mediates inflammation and fibrosis during diseases of various organs, including the heart, lung, kidney, skin, liver, skeletal muscle and retina.
This study evaluated periostin levels in gingival crevicular fluid from patients with chronic periodontitis, gingivitis and periodontally healthy as well as the effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with chronic periodontitis | Experimental | Patients with CP (n=30) had teeth with 30% periodontal bone loss and ≥ 2 non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and bleeding on probing. |
|
| Patients with gingivitis | Experimental | Participants with G (n=30) had gingival index ≥ 2 and other inflammation signs. |
|
| Participants with periodontal healthy | No Intervention | The H group (n=30) consisted of individuals with no attachment loss, no history of periodontal disease, PD ≤3 mm, and whole-mouth bleeding scores <10%. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-Surgical Periodontal Treatment | Procedure | Scaling and root planing and polishing with specific curettes were performed to patients and oral hygiene education was provided to each patient. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in periostin | Total amount of Periostin (pg/30 sec) in gingival crevicular fluid | Baseline, 6th week and 3rd month |
| Measure | Description | Time Frame |
|---|---|---|
| Change in periodontal clinical parameter | Clinical attachment level (mm) (from cemento-enamel junction to the base of periodontal pocket) | Baseline, 6th week and 3rd month |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D055113 | Chronic Periodontitis |
| D005891 | Gingivitis |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010518 | Periodontitis |
| D002908 | Chronic Disease |
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|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007239 | Infections |
| D005882 | Gingival Diseases |