The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.

The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

Inclusion Criteria:

• Over 18 years of age
• Patients who underwent cardiac surgery for a single valve change or replacement

Exclusion Criteria:

• Stage 3 renal failure patients
• Patients with a previous diagnosis of hematological malignancy
• Patients undergoing pulmonary valve change surgery.
• Patients undergoing Bentall and Bono surgery.
• Patients Undergoing Coronary Artery Bypass Surgery

Patients who meet the selection criteria undergoing cardiac surgery for a single valve change or replacement.