Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome

Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome

Women with androgen excess polycystic ovary syndrome (AE-PCOS) leads to hypertension.

Our scientific premise is that in AE-PCOS women, the androgen-dominant hormonal milieu causes BP increases via sympathetic activation, vasoconstriction and renal sympathetic nervous system activation. Moreover, this androgen-dominant milieu increases BP via activation of the renin-angiotensin system.

Inclusion Criteria:

• Clinical Diagnosis of Polycystic Ovary Syndrome
• Able to inject study drug
• Able to swallow pills

Controls:

-Diagnosis of Insulin resistance

Exclusion Criteria:

• Any woman that does not fit the inclusion criteria
• Males