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Knee osteoarthritis (OA) is a debilitating disease affecting millions of Canadians. Exercise is a core treatment for knee OA, and is advocated by all clinical guidelines. However, the safety of recreational running in the presence of knee OA is unclear. There are no studies available to provide direct data to appropriately inform runners and clinicians whether running should be advocated for joint health. Our research study will address this gap.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Running volume increase | Experimental | Participants will be be given a running program based on their running mileage on inclusion and supported by regular contacts with the study trainer. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Running volume increase | Behavioral | Participants will receive a 12-week running program to increase their running volume by approximately 10% per week on average, and in accordance with the "10% rule" advocated to minimize injury rates. For the purpose of this study, participants will run using their habitual technique - i.e. no specific instructions on 'how' to run will be provided; rather, they will simply be instructed on 'how much' to run. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline to 12 weeks in T2 relaxation time of the medial femoral cartilage | T2 relaxation represents the time constant of the molecular motion of water in cartilage, which is influenced by the composition of collagen and specifically reflects changes to the extracellular matrix. This constant is assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T2 relaxation time of the medial tibial cartilage | T2 relaxation represents the time constant of the molecular motion of water in cartilage, which is influenced by the composition of collagen and specifically reflects changes to the extracellular matrix. This constant is assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T2 relaxation time of the lateral femoral cartilage | T2 relaxation represents the time constant of the molecular motion of water in cartilage, which is influenced by the composition of collagen and specifically reflects changes to the extracellular matrix. This constant is assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T2 relaxation time of the lateral tibial cartilage | T2 relaxation represents the time constant of the molecular motion of water in cartilage, which is influenced by the composition of collagen and specifically reflects changes to the extracellular matrix. This constant is assessed using MRI. | Baseline, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline to 12 weeks in T1ρ relaxation time of the medial femoral cartilage | T1ρ provides an indication of glycosaminoglycan concentration in cartilage assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T1ρ relaxation time of the medial tibial cartilage |
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Inclusion Criteria:
ALL:
TFOA Group:
Control Group:
Exclusion Criteria:
ALL:
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| Name | Affiliation | Role |
|---|---|---|
| Michael A Hunt, PT, PhD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Motion Analysis and Biofeedback Laboratory, The University of British Columbia | Vancouver | British Columbia | V6T 1Z3 | Canada |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Nov 30, 2019 | Mar 25, 2020 | Prot_000.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Nov 30, 2019 | Mar 25, 2020 | SAP_001.pdf |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| D010003 | Osteoarthritis |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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Both runners with and without knee osteoarthritis will be recruited. They will all receive the same intervention.
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|
T1ρ provides an indication of glycosaminoglycan concentration in cartilage assessed using MRI. |
| Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T1ρ relaxation time of the lateral femoral cartilage | T1ρ provides an indication of glycosaminoglycan concentration in cartilage assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in T1ρ relaxation time of the lateral tibial cartilage | T1ρ provides an indication of glycosaminoglycan concentration in cartilage assessed using MRI. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint loading: peak knee adduction moment | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint loading: knee adduction moment impulse | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint loading: peak flexion moment | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint loading: flexion moment impulse | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint kinematics: peak knee flexion angle | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee joint kinematics: knee joint angle excursion | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in foot strike pattern | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in step rate | Participants will run on an instrumented treadmill in their habitual running shoes while analyzed using three-dimensional motion analysis. Kinematic (joint angle) and kinetic (joint loading) data will be collected synchronously using high-speed digital cameras and treadmill-embedded force platforms. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee symptoms: Knee Osteoarthritis Outcome Score (KOOS) | Validated questionnaire on symptoms and functional limitations related to knee osteoarthritis. The score is expressed in percentage (0-100), with 0 representing extreme knee problems and 100 representing no knee problems. | Baseline, 12 weeks |
| Change from Baseline to 12 weeks in knee symptoms: Visual Analog Scale | Knee pain during and after running will be assessed for each training. The minimum value is "No Pain" and the maximum value is "Worst Pain Imaginable". Each week of training will be averaged. | Baseline to 12 weeks, averaged weekly |
| Change from Baseline to 12 weeks in weekly running distance | Participants will record their weekly running distance using an online diary. | Baseline to 12 weeks, averaged weekly |