| Primary | Number of Participants With Treatment Success | Defined as the number of patients not requiring invasive mechanical ventilation or Extracorporeal membrane oxygenation (ECMO) | | Posted | | Count of Participants | | Participants | | Up to Day 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| | | Title | Denominators | Categories |
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| Secondary | Number of Participants Requiring Mechanical Ventilation | Measured in number of participants | | Posted | | Count of Participants | | Participants | | Date of randomization to date of mechanical ventilation, up to 15 Days | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Modified Early Warning System Score | The full (unabbreviated) scale name is Modified Early Warning system score (MEWS score) Measured in total score Total score is the sum of 5 categorized components (blood pressure, heart rate, respiratory rate, temperature and alert/voice/pain/unresponsive score) that are assigned a score between 0 and 2 or 0 and 3. MEWS total score range is 0 to 14. Higher score= worse outcome | | Posted | | Mean | Standard Deviation | scores on a scale | | Baseline, Day 15 | | | | ID | Title | Description |
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| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Ferritin | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | pmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Lactate Dehydrogenase (LDH) | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | U/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in D-dimers | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | nmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Resting Peripheral Capillary Oxygen Saturation (SpO2) | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | SpO2% | | Baseline, 3 assessments every Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Oxygen Supplementation | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | L/min | | Baseline, Days 4, 7, 10, 13 and 15. | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Partial Pressure of Oxygen/Fraction of Inspired Oxygen (PaO2/FiO2) | | Change from baseline at Day 15 Data not available for the whole population | Posted | | Mean | Standard Deviation | mmHg | | Baseline, Day 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Number of Participants With Changes in High-resolution Computed Tomography (CT) Scan of the Chest | Measured in scan evaluation: Normal, Abnormal but not clinically significant, Abnormal clinical significant, Not Done | Data not available for all patients | Posted | | Count of Participants | | Participants | | Screening, Day 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day Abnormal CS at screening | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion Abnormal CS at screening | | OG002 | Standard of Care | Standard of care according to local practice Abnormal CS at screening |
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| Secondary | Overall Survival | | | Posted | | Count of Participants | | Participants | | Weeks 6 and 10 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Number of Patients With Hospital Discharge | Measured in number of patients | | Posted | | Count of Participants | | Participants | | Until discharge up to Week 10 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Carbon Dioxide Tension (pCO2) in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmHg | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Oxygen Tension (pO2) in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmHg | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Potassium in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Sodium in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Chloride in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Lactic Acid in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | mmol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change of Hemoglobin in Hemogasanalysis From Baseline | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | g/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in White Blood Cells With Differential Counts | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | 10^9 cells /L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Red Blood Counts | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | 10^12 cells/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Hemoglobin | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | g/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Platelet Count | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | 10^9 cells /L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Fibrinogen | | Change from baseline at Days 4, 7, 10, 13 and 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | umol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Complement Factors C3/C4 | | Change from baseline at Day 15 | Posted | | Mean | Standard Deviation | g/L | | Day 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Prothrombin Time | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | sec | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |
| Secondary | Change From Baseline in Cardiac Troponin | | Change from baseline at Day 15 Data not available for the whole population | Posted | | Mean | Standard Deviation | ug/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |
| Secondary | Change From Baseline in Aspartate Aminotransferase (AST) | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | U/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |
| Secondary | Change From Baseline in Alanine Aminotransferase (ALT) | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | U/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
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| Secondary | Change From Baseline in Total Bilirubin Levels | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | umol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |
| Secondary | Change From Baseline in C-Reactive Protein | | Change from baseline at Day 15. Data not available for the whole population | Posted | | Mean | Standard Deviation | mg/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |
| Secondary | Change From Baseline in Creatinine | | Change from baseline at Day 15 Data not available for all patients at all timepoints | Posted | | Mean | Standard Deviation | umol/L | | Baseline, Days 4, 7, 10, 13 and 15 | | | | ID | Title | Description |
|---|
| OG000 | Emapalumab | Emapalumab i.v. infusion every 3rd day for a total 5 infusions. Day 1: 6mg/kg. Days 4, 7, 10 and 13: 3 mg/kg Emapalumab: I.v. infusion every third day | | OG001 | Anakinra | Anakinra i.v. infusion four times daily for 15 days. 400 mg/day in total, divided into 4 doses given every 6 hours Anakinra: Daily i.v. infusion | | OG002 | Standard of Care | Standard of care according to local practice |
| |