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The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).
A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest.
20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meal with medium chain triglycerdies first | Experimental | Arm 1: participants randomized to receive the mixed meal with medium chain triglycerides first. |
|
| Meal with medium chain triglycerdies second | Active Comparator | Arm 2: participants randomized to receive the mixed meal without medium chain triglycerides first.te |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mixed meal with medium chain triglycerides | Dietary Supplement | Mixed macronutrient liquid meal (1.6kcal/ml, 15% protein, 47% carbohydrates, 35% fat, 3% fiber) with medium chain triglycerides (3g/100 kcal). An amount with energy supply equivalent to their 50% basal metabolic rate. |
| Measure | Description | Time Frame |
|---|---|---|
| Post-prandial nutrient oxidation | Fat or carbohydrate oxidation measured by indrect calorimetry | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Post-prandial blood glucose concentrations | Measures of blood glucose concentrations | 4 hours |
| Post-prandial blood insulin concentrations | Measures of blood insulin concentrations |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jonatan Ruiz Ruiz, Dr. | Contact | 958242754 | 34 | ruizj@ugr.es |
| Lucas Jurado Fasoli, PhD student | Contact | juradofasoli@ugr.es |
| Name | Affiliation | Role |
|---|---|---|
| Jonatan Ruiz Ruiz, Dr. | Universidad de Granada | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jonatan Ruiz Ruiz | Recruiting | Granada | 18011 | Spain |
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Crossover Assignment
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|
| Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides | Dietary Supplement | Mixed macronutrient liquid meal (1.6kcal/ml, 15% protein, 47% carbohydrates, 35% fat, 3% fiber) without medium chain triglycerides (replaced it with long chain triglycerides). An amount with energy supply equivalent to their 50% basal metabolic rate. |
|
| 4 hours |
| Post-prandial blood non-esterified fatty acid concentrations | Measures of blood non-esterified fatty acid concentrations | 4 hours |
| Post-prandial blood tryglicerides concentrations | Measures of blood tryglicerides concentrations | 4 hours |
| Post-prandial blood cholesterol concentrations | Measures of blood cholesterol concentrations | 4 hours |
| Post-prandial blood glycerol concentrations | Measures of blood glycerol concentrations | 4 hours |
| Post-prandial blood lactate concentrations | Measures of blood lactate concentrations | 4 hours |
| Post-prandial energy expenditure | Measured by indrect calorimetry | 4 hours |
| Post-prandial sensations related to appetite | Measured by visual analogue scales (VAS). Score ranging from 0 to 100mm. Higher values mean the most positive rating, while lower values mean the most negative rating. | 4 hours |
| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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