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| Name | Class |
|---|---|
| NUCITEC S.A. de C.V. | UNKNOWN |
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Milk proteins and micronutrients could be beneficial in the prevention and treatment of obesity.
The objective was to evaluate a supplement with milk proteins and multivitamins and minerals with nutrition education on anthropometry, body composition, micronutrient status, blood pressure, lipid profile, systemic inflammation, leptin and insulin resistance in obese children at baseline and after 6 months.
Obese children were selected in elementary schools from 5 rural communities of the State of Querétaro. One hundred fifty two obese children (Z-score >2 standard deviations) aged 6-11y were randomly assigned to receive one of two treatments: 1) 237mL/day of milk proteins and multiple micronutrients supplement (MPMS) plus Nutrition Education (NE) program or 2) NE alone for 24 weeks.
Children in both groups were evaluated at baseline and 6 months after treatment initiated. At both times the following variables were evaluated:
Visit 1 (Screening): Mothers and parents received oral and written information regarding all aspects of the study. Informed consent, medical history, demographic information, weight and height were obtained.
Visit 2 (Clinical Laboratory testing): A blood preasure and sample was taken by an specialist. Blood test included Glucose, total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol, Tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10), C reactive protein, insulin and leptin.
Visit 3 (Nutrition Clinic at UAQ): body composition was determined by DEXA. The NE were given at Nutrition Clinic and school to the children's parents each week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplement with micronutrients | Experimental | Nutrition education with a supplement |
|
| Nutrition education | Experimental | Group received only nutrition education |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supplement with micronutrients | Dietary Supplement | Obese children were divided in 2 groups. A group received the supplement plus nutrition education and other group was a control, only received nutrition education. |
| Measure | Description | Time Frame |
|---|---|---|
| Total body fat | change in fat | baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol | Change in total cholesterol | Beaseline to 6 months |
| HDL | change in HDL | Baseline to 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D063766 | Pediatric Obesity |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D018977 | Micronutrients |
| D015596 | Nutrition Assessment |
| ID | Term |
|---|---|
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D000078622 | Nutrients |
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Control group received only nutrition education and treated group received nutrition education plus a supplement with milk protein and micronutrients.
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| Nutrition education | Other | Group received nutrition education program during 6 months |
|
| LDL | change in LDL | baseline to 6 months |
| Triglycerides | change in triglycerides | baseline to 6 months |
| Glucose | change in glucose | baseline to 6 months |
| Interleukin 6 (IL-6) | Change in IL-6 | baseline to 6 months |
| Interleukin 10 (IL-10) | change of IL-10 change in IL-10 | baseline to 6 months |
| C reactive protein (CRP) | change of CRP | baseline to 6 months |
| Bone mineral density (BMD) | change in BMD | baseline to 6 months |
| Body mass index (BMI) | Change in BMI | Baseline to 6 months |
| Zinc levels | Change in zinc levels | baseline to 6 months |
| Iron levels | Change in iron levels | baseline to 6 months |
| A vitamin levels | change in A vitamin levels | baseline to 6 months |
| C vitamin levels | change of C vitamin levels | baseline to 6 months |
| D vitamin levels | change in D vitamin levels | baseline to 6 months |
| E vitamin levels | change of E vitamin levels | baseline to 6 months |
| Systolic blood pressure (SBP) | change in SBP | baseline to 6 months |
| Diastolic blood pressure (DBP) | change in (DBP) | baseline to 6 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |