Knee Steroid Injection and Blood Sugar Signatur

Identifying Variables Associated With Steroid-Induced Hyperglycemia Following Intra-articular Knee Injections Among Diabetic Patients

A prospective, observational study assessing the relationship between HbA1c level and the post-injection blood glucose signature. Participants will be non-diabetic, pre-diabetic, non-insulin dependent and insulin dependent type 2 diabetic patients who will be receiving a knee steroid injection. All of them will be consented a week prior to the injection, when the CGM sensor will be applied to the back of the upper arm. This will be removed a week after the injection. KOOS survey as well as VAS will be administered. Adverse events (e.g., change in medication or hospitalization) will be monitored throughout the study.

Inclusion Criteria:

• Patients at the Parkland Outpatient Clinic
• Indication for unilateral knee joint steroid injection for the treatment of knee joint osteoarthritis

Exclusion Criteria:

• Less than 18 years old
• HbA1c > 12.0%
• steroid exposure in the 3 months prior to Visit 1
• 3 or more steroid injections in the preceding 12 months
• known contraindication to steroid injection (adverse reaction or allergy, active infection, INR > 3.0)
• lack of improvement with prior knee steroid injection
• change in diabetic medication regimen in the last 1 month
• significant change in diet within the last 1 month
• current use of aspirin
• allergy to adhesive
• planned MRI, XR, or CT during the 2-week study period