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The aim of the study is to analyze cardiac biomarkers, electrocardiograms and cardio-pulmonary exercise test (CPET) results in children with cardiomyopathies.
The study group will consist of children that have been diagnosed with DCM, HCM or LVNC. The control group will be composed of healthy children. Examination of cardiac biomarkers (in the study group), ECG, 24-hour- ECG monitoring, CPET will be performed.
Patients in the study group will be invited for 2 consecutive visits (in 6-10 months intervals). During the first and the last visit CPET will be performed. The control group will not be invited for consecutive visits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with cardiomyopathies | Children aged 0-18 years that have been diagnosed with DCM, HCM or LVNC on the basis of a two-dimensional echocardiography with color Doppler. |
| |
| Healthy children | The control group will be composed of healthy children, in whom heart disease will be excluded using echocardiography. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ECG | Diagnostic Test | ECG will be performed during each visit in the study group. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of ECG (electrocardiographic) differences in children with cardiomyopathies and healthy children. | Assessment of heart rhythm, heart rate (BPM), PQ, QRS, QT, QTc intervals, QRS-T angle and arrythmia in ECG. These will be compared with arrythmia severity in 24-hour ecg monitoring. | 14 months |
| Assessment of differences in CPET results in children with cardiomyopathies and healthy children. | Assessment of peak respiratory oxygen uptake (peakVo2), carbon dioxide production (Vco2), anaerobic threshold (AT), expired ventilation (VE), ventilatory equivalent for CO2 (VE/VCO2), VO2/Work rate relationship, maximal workload (W), duration of exercise (T). | 14 months |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of progression of heart failure in children with cardiomyopathies | Assessment of serum cardiac biomarkers (Troponin I, NT-proBNP) in children with cardiomyopathies during each visit. | 20 months |
| Assessment of arrhythmia in time in children with cardiomyopathies |
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Inclusion Criteria:
Exclusion Criteria:
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The study group will consist of children aged 0-18 years that have been diagnosed with DCM, HCM or LVNC who are under the care of our Deparment.
The control group will be composed of 30 healthy children, in whom heart disease will be excluded using echocardiography.
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| Name | Affiliation | Role |
|---|---|---|
| Katarzyna M Luczak-Wozniak, MD | Medical Univeristy of Warsaw, Poland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Univeristy of Warsaw | Warsaw | Poland |
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| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D004562 | Electrocardiography |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| 24-hour ECG monitoring | Diagnostic Test | 24-hour ECG monitoring will be performed during each visit in the study group. |
|
| Cardio-pulmonary exercise test (CPET) | Diagnostic Test | CPET will be performed during the first and the last visit in the study group. |
|
| Cardiac biomarkers | Diagnostic Test | Cardiac biomarkers will be assessed during each visit in the study group. |
|
Assessment of heart rhythm, heart rate (BPM), PQ, QRS, QT, QTc intervals, QRS-T angle and arrythmia in ECG during each control visit. The results will be compared to the severity of arrythmia in 24-hour ecg monitoring. These test will be performed during each visit. |
| 20 months |
| Assessment of changes in CPET results in children with cardiomyopathies | Assessment of peak respiratory oxygen uptake (peakVo2), carbon dioxide production (Vco2), anaerobic threshold (AT), expired ventilation (VE), ventilatory equivalent for CO2 (VE/VCO2), VO2/Work rate relationship, maximal workload (W), duration of exercise (T). CPET will be performed in during the first and the last control visit. | 20 months |
| D004568 | Electrodiagnosis |