Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.

Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.

The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.

During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.

At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.

Inclusion Criteria:

• healthy
• higher uric acid concentration (≥5.5 mg/dL)
• Informed written consent

Exclusion Criteria:

• pregnancy
• fructose intolerance
• smoking
• gout or medicated hyperuricemia
• diabetes mellitus
• antidiabetic or cytostatic medication
• weight loss (≥5% in the past 3 months)
• consumption of vitamin C-containing supplements
• parallel participation in a clinical trial
• anemia and / or iron deficiency