Stem Cell and Conditioned Medium for Cerebral Palsy

Allogeneic Umbilical Cord Mesenchymal Stem Cells and Conditioned Medium for Cerebral Palsy in Children

The aim of this study was to compare the effectiveness of umbilical cord mesenchymal stem cells (UCMSCs) and conditioned medium (CM) administration, UCMSCs only and control with standard therapy.

Hypothesis: UCMSCs + CM therapy resulting in higher improvement in cognitive function, gross motor function and chemical factors than UCMSCs and standard therapy.

Inclusion Criteria:

• Diagnosed as Cerebral palsy with total body involvement type
• Age between 6 month - 3 years old
• Parents requesting for cell therapy
• The parents give sign in informed consent form do to examination, therapy, blood sampling collection and observation for their child

Exclusion Criteria:

• Head circumference less than -3 SD (more than 3 cm) Nellhaus standard
• Have diagnosed meningitis and encephalitis
• Have diagnosed congenital infection i.e. toxoplasmosis, rubella congenital, cytomegalovirus
• Have diagnosed metabolic disorder, chromosome disorder, congenital malformation or neuroregeneratif disease
• Progressive disorder
• Regressive development disorder
• Severe anatomical abnormalities in Brain MRI