Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis

Innovative Osteoarthritis Therapy Using Combination of Mesenchymal Stem Cell (MSC) and Conditioned Medium (CM): A Comparative Study on Arthroscopy and Non-Arthroscopy

This study aims to compare the efficacy of Umbilical Cord Mesenchymal Stem Cell and secretome between arthroscopy and without arthroscopy intervention in OA patients. This study has 4 arms namely Arthroscopy + Booster, Arthroscopy + Pre-conditioning, Non-Arthroscopy + Booster, Non-Arthroscopy + Pre-conditioning.

The study subjects each group amounted to 5 patients suffering from osteoarthritis. Patients are evaluated before, and 1,3,6 months after injection.

Inclusion Criteria:

• Patients aged 55-70 years
• Suffering from grade 2-3 OA was identified by two observers who differed accordingly Kellgren-Lawrence research scale
• Absence of local or general infections
• Haematological and biochemical analysis without significant changes being made cause contraindications
• Patients can understand the nature of the study
• Written informed consent is given to patients

Exclusion Criteria:

• Patients are not willing to obey the study protocol
• There are signs of infection or positive serology for HIV, hepatitis and syphilis
• There is a history of cancer both in the family and yourself and the value of the examination tumour marker exceeds normal limits
• There is a congenital disease that causes significant deformity of the knee can interfere with cell applications and interpret results
• Articular injection of the knee by any drug during the previous 3 months
• Participate in any clinical trial or treatment 30 days before the study
• Other conditions may, according to medical criteria, not support participation in this research
• Patients are subordinates or low ranking members