Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented [1-6]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SAH patients with nimodipine | Patients with SAH receiving nimodipine as prevention of vasospasms and as a nootropic drug. | ||
| SAH patients without nimodipine | Patients with SAH not receiving nimodipine as prevention of vasospasms and as a nootropic drug or in whom the drug has been temporarily discontinued. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Functional capillary density (FCD) | Parameter describing the perfusion of the microcirculation | One week |
| Proportion of perfused vessels (PPV) | Parameter describing the perfusion of the microcirculation | One week |
| Measure | Description | Time Frame |
|---|---|---|
| Vasospasm occurence | Occurence of vasospasms on angiography and/or transcranial Doppler | One week |
| Circulatory incoherence | Deranged microcirculation in patients on catecholamines |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
All adult patients admitted to the neurosurgical ICU with the diagnosis of subarachnoid hemorrhage. Might be alert, somnolent or sedated on mechanical ventilation. Might be after endovascular coiling or surgical clipping of the aneurysm.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Astapenko, M.D., Ph.D. | Contact | +420608177374 | david.astapenko@fnhk.cz |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Hradec Kralove | Recruiting | Hradec Králové | Třebeš | 50005 | Czechia |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| One week |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |