This study is to investigate the long-term outcomes and prognostic risk factors in patients recovered from hepatitis B virus related acute on-chronic liver failure.

Chronic acute liver failure (ACLF) is a systemic multi-organ failure driven by acute liver injury in the basis of chronic liver disease. The main cause of chronic acute liver failure in China is hepatitis b virus infection.Previous studies on the prognosis of acute on-chronic liver failure mainly focused on the short-term survival rate and the follow-up time was relatively short, while the study on the long-term prognosis of patients with spontaneous recovery of chronic acute liver failure was still lack-ing. Thus,this study mainly retrospectively analyzed the clinical data of patients with chronic hepatitis b related acute liver failure admitted to the department of infectious diseases, the third affiliated hospital of sun yat-sen university, and con-ducted telephone follow-up survey to analyze the long-term prognosis of patients with chronic hepatitis b related acute on-chronic liver failure.

Inclusion Criteria:

• Age from 18 to 65 years old;
• The diagnosis consistent with hepatitis b associated chronic acute liver failure；
• After hospitalization, the survival time > 90 days；
• The inpatient clinical data are complete.

Exclusion Criteria:

• Human immunodeficiency virus infection or congenital immune deficiency diseases;
• Liver cancer and other tumors, autoimmune liver disease, genetic and metabolic liver disease, or other serious diseases that significantly affect patient survival;
• Other conditions that the researchers judged not appropriate for inclusion.

This study population were patients with hepatitis b-related acute on-chronic liver failure in the department of infectious diseases, the third affiliated hospital of sun yat-sen university.

Individual participant data that underline the results reported in this article (text, tables, figures and appendices) will be shared.

The data will be shared beginning 3 months and ending 5 years following the article publication.

Proposals should be directed to xxx@yyy. To gain access, data requestors need to sign a data access agreement.