The aim of the current project is the development and implementation of an e-health database of drug interactions (drug-drug, drug-food, drug-alcohol and drug-herbal products interaction) to CKD patients in order to achieve a holistic approach to patient care and personalized medicine. The study will be conducted in the University of Ioannina (cooperation between the Department of Nephrology and the Laboratory of Physiology). Data will be collected form 150 CKD patients (Stages 1-5 pre-dialysis, undergoing dialysis, kidney transplantation). Sixty patients will be selected for the pilot study which will include blood and urine tests and specific polymorphism analysis (pharmacogenetic tests). Pilot implementation of the e-health database will be undertaken by health professionals of the Department of Nephrology (University Hospital of Ioannina) to test the system in realistic setting (usability, efficiency and efficacy) in order to make the necessary changes prior to full scale deployment.

Inclusion Criteria:

• Age>18 years
• CKD diagnosis according to KDOQI Guidelines
• absence of active malignancy
• absence of decompensated heart failure New York Heart Association (NYHA) IV
• absence of liver cirrhosis
• patient's consent

Exclusion Criteria:

• Age<18 years
• active malignancy
• decompensated heart failure NYHA IV
• liver cirrhosis
• patient's refusal to participate in the study

150 patients with Chronic Kidney Disease (stages 1-5 pre-dialysis, kidney transplantation) from the Nephrology Department of University Hospital of Ioannina