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Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.
To examine the response of therapy on visual functions in amblyopic and strabismic participants.
The following visual functions will be measured prior to treatment. Eye movements, contrast sensitivity, grating acuity, visual acuity, vernier acuity, binocular visual functions, reading and visual scanning will be measured. The testing will comprise of one or more of the above paradigms depending on participant's cooperation and understanding as majority of the study participants will be children. The above measurements will be repeated during amblyopia therapy ( which comprises of glasses, patching and/or atropine eye drops) and at the completion of treatment. For participants with strabismus requiring strabismus surgery the measurements will be repeated after strabismus surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control subjects | Subjects who state they have no eye or neurologic problems or disease other than perhaps wearing glasses or contact lenses and upon review of medical history. | ||
| Amblyopia | Clinical diagnosis of amblyopia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patching therapy, Glasses | Behavioral | Patching, glasses and strabismus surgery are commonly employed measures in treatment of amblyopia and strabismus. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Functions | contrast sensitivity | 0-3 years depending on duration of treatment |
| Visual Functions | visual acuity | 0-3 years depending on duration of treatment |
| Visual functions | vernier acuity | 0-3 years depending on duration of treatment |
| Visual functions | grating acuity | 0-3 years depending on duration of treatment |
| Visual functions | binocular functions- stereopsis, inter-ocular functions | 0-3 years depending on duration of treatment |
| Visual functions | eye movement measurements | 0-3 years depending on duration of treatment |
| Visual functions | reading- reading speeds, eye movement measurements | 0-3 years depending on duration of treatment |
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Inclusion Criteria:
Exclusion Criteria:
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children with diagnosis of strabismus and/or amblyopia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kimberly Baynes, MSN | Contact | 216-444-2566 | baynesk@ccf.org |
| Name | Affiliation | Role |
|---|---|---|
| Fatema Ghasia, MD | The Cleveland Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cleveland Clinic | Recruiting | Cleveland | Ohio | 44195 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16213398 | Background | Chatzistefanou KI, Theodossiadis GP, Damanakis AG, Ladas ID, Moschos MN, Chimonidou E. Contrast sensitivity in amblyopia: the fellow eye of untreated and successfully treated amblyopes. J AAPOS. 2005 Oct;9(5):468-74. doi: 10.1016/j.jaapos.2005.05.002. | |
| 26930079 | Result | Shaikh AG, Otero-Millan J, Kumar P, Ghasia FF. Abnormal Fixational Eye Movements in Amblyopia. PLoS One. 2016 Mar 1;11(3):e0149953. doi: 10.1371/journal.pone.0149953. eCollection 2016. |
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Research publications require inclusion of de-identified data in the manuscript. We will also be presenting the data at local, national and international conferences.
starting 6 months after publication
The de-identified research data will be shared with colleagues and will be published after peer-review.
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| ID | Term |
|---|---|
| D000550 | Amblyopia |
| D013285 | Strabismus |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014786 | Vision Disorders |
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| ID | Term |
|---|---|
| D005139 | Eyeglasses |
| ID | Term |
|---|---|
| D007909 | Lenses |
| D055096 | Optical Devices |
| D004864 | Equipment and Supplies |
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|
| 28698242 | Result | Ghasia FF, Otero-Millan J, Shaikh AG. Abnormal fixational eye movements in strabismus. Br J Ophthalmol. 2018 Feb;102(2):253-259. doi: 10.1136/bjophthalmol-2017-310346. Epub 2017 Jul 11. |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D015835 | Ocular Motility Disorders |
| D003389 | Cranial Nerve Diseases |