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| Name | Class |
|---|---|
| Mitacs | INDUSTRY |
| Core-Health Technologies Inc. | UNKNOWN |
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Recent evidence suggests that hyperinsulinemia (i.e., elevated insulin levels) is the primary causative factor in obesity. Insulin promotes fat storage and prevents fat breakdown, suggesting that weight loss would be optimized if insulin levels are managed and kept low. Understanding how different foods impact insulin levels could therefore aid in personalized weight loss (or weight maintenance) advice. It has been shown that salivary insulin can track plasma insulin following different meals and can delineate between lean and obese people. Thus, it was suggested that salivary insulin could be a potential surrogate for plasma insulin. The purpose of this study is to measure fasting saliva insulin, and salivary insulin responses to a standardized meal tolerance test in individuals with different body mass index (BMI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salivary insulin responses to mixed meal tolerance test | Experimental | Saliva samples and finger prick glucose will be collected after at least 4 hours of fasting and then at 60 and 90 minutes following ingestion of a standardized meal tolerance test. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary intervention | Other | Salivary insulin responses to a standardized mixed meal |
|
| Measure | Description | Time Frame |
|---|---|---|
| Saliva insulin area under the curve | The saliva insulin concentration measured by enzyme-linked immunosorbent assay - Area under the curve will be measured using the trapezoidal rule. | Measured for 90 minutes following the meal (time points: fasting, 60 minutes, and 90 minutes) |
| Saliva insulin at different time points | Saliva insulin will be collected and measured by enzyme-linked immunosorbent assay. | Salivary insulin at fasting (at least 4 hours of fasting), and at 60 and 90 minutes following mixed meal ingestion) |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose area under the curve | Finger prick glucose concentration measured by glucometer - Area under the curve will be measured using the trapezoidal rule. | Measured for 90 minutes following the meal (time points: fasting, 60 minutes, and 90 minutes) |
| Glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia Okanagan | Recruiting | Kelowna | British Columbia | V1V 3G1 | Canada |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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Finger prick glucose at different time points will be measured by a glucometer. |
| Finger prick glucose will be measured at fasting (at least 4 hours of fasting), and at 60 and 90 minutes following mixed meal ingestion) |