Ovarian Fragmentation Study (Crespo Medical Team)

Ovarian Fragmentation Study (Crespo Medical Team)

This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following this procedure in poor ovarian responders and patients with decreased ovarian reserve. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.

Inclusion Criteria:

• Abdominal surgery need for fertility cause.
• Bad embryo quality (>2 cycles with < 1 embryo A-B quality. With:

A. Poor ovarian responders (previous ≤ 3 retrieved metaphase II oocytes) in a conventional cycle.

B. Decreased ovarian reserve (antral follicle count (AFC) ≤ 5 or antiMullerian hormone (AMH) ≤ 0.5 ng/mL).

C.Premature ovarian insufficiency according to:

• Patients < 40 years old.
• At least 1 year of amenorrhea.
• Follitropin serum levels (FSH) >35 IU/ml in two serum samples separated by at least 1 month.
• Estradiol serum levels (E2) < 20 pg/mL.

Exclusion Criteria:

1. Clinical/ultrasonographical signs of severe endometriosis ( or endometrioma).
2. Age over 45 years (EMC)
3. Previous ovarian/pelvic surgery. Unilateral oophorectomy.
4. Body Mass Index > 30
5. Previous gonadotoxic treatment.
6. Genito-urinary tract malformations.
7. Inform consent unsigned.