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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG057671-01A1 | U.S. NIH Grant/Contract | View source |
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COVID-19 safety restrictions
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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Motor skill training therapy aims to improve the brain's control of walking and can improve clinic-based measures of walking in older adults. However, it is unknown whether the benefits of motor skill training extend to real world mobility measures. The investigators will test the effects of motor skill training on measures of community mobility of older adults and assess the mechanisms through improved motor control at the level of the brain. These results will inform intervention approaches to maintain community mobility of older adults and prevent disability and institutionalization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard | Active Comparator | The standard arm consists of strength, endurance and flexibility exercises 2 times per week for 12 weeks. Will also receive a physical activity behavioral intervention. |
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| Standard-plus | Experimental | The standard-plus arm consists of strength, endurance and flexibility exercises plus task specific timing and coordination exercises to improve gait 2 times per week for 12 weeks. Will also receive a physical activity behavioral intervention. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strength training | Behavioral | weight lifting to increase muscle strength |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in oxygenated hemoglobin at the prefrontal cortex from standing to walking | Physiologic measure indicative of usage of the prefrontal cortex during a task recorded by optical imaging (near infrared spectroscopy). | change from baseline to 12 weeks |
| Change in oxygenated hemoglobin at the prefrontal cortex from standing to walking | Physiologic measure indicative of usage of the prefrontal cortex during a task recorded by optical imaging (near infrared spectroscopy). | change from baseline to 36 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Gait speed | Walking speed (m/s) during usual pace | 12, 24, and 36 weeks |
| Gait speed | Walking speed (m/s) with a cognitive challenge. |
| Measure | Description | Time Frame |
|---|---|---|
| Activity Space | Extent of travel beyond the home collected by GPS device based on a standard deviation ellipse of spatial measurement points. | 12, 24, and 36 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrea L Rosso, PhD, MPH | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15219 | United States |
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| ID | Term |
|---|---|
| D020233 | Gait Disorders, Neurologic |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| D000076663 | Endurance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Endurance training | Behavioral | treadmill walking to increase endurance |
|
| Flexibility training | Behavioral | stretches to improve flexibility |
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| Physical activity behavioral intervention | Behavioral | Intervention to encourage participants to be more physically active |
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| Task Specific timing and coordination training | Behavioral | stepping and walking patterns to improve timing and coordination of gait |
|
| 12, 24, and 36 weeks |
| Gait speed | Walking speed (m/s) on an uneven surface. | 12, 24, and 36 weeks |
| Gait variability | Fluctuations in gait characteristics from step to step during usual pace. Physiologic measure of temporal gait characteristics (standard deviation). | 12, 24, and 36 weeks |
| Gait variability | Fluctuations in gait characteristics from step to step while walking with a cognitive challenge. Physiologic measure of temporal gait characteristics (standard deviation). | 12, 24, and 36 weeks |
| Gait variability | Fluctuations in gait characteristics from step to step while walking on an uneven surface. Physiologic measure of temporal gait characteristics (standard deviation). | 12, 24, and 36 weeks |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |