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Researchers are trying to find out whether the use of low-intensity strength exercises during the 2 weeks before surgery, and while the blood flow to the leg is reduced, will improve the outcomes after surgery to repair an injured ligament of the knee.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blood Flow Restriction (BFR) group | Experimental | Subjects previously diagnosed with a torn ACL who have yet to undergo surgical reconstruction and pre-operative rehabilitation will do a series of low-intensity strength exercises while the blood flow to the leg is reduced by a blood flow restriction cuff. |
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| SHAM Blood Flow Restriction (BFR) group | Sham Comparator | Subjects previously diagnosed with a torn ACL who have yet to undergo surgical reconstruction and pre-operative rehabilitation will do a series of low-intensity strength exercises while a blood flow restriction cuff is applied but inflation pressure will be limited |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Blood Flow Restriction training | Behavioral | While exercising, an Inflatable cuff, similar to a blood pressure cuff, is applied to the proximal aspect of the femur of the affected lower extremity inflated to occlude blood flow |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle diameter (hypertrophy) | Measured using ultrasound images of the musculature and soft tissue of the quadriceps femoris | 2 weeks pre-operative, 8-10 days post-operative |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle strength | Muscle strength will be measured in subjects as the percent strength of the injured leg compared to the non-injured leg based on handheld dynamometer and the number of leg presses performed at the 1-rep maximum | 2 weeks pre-operative, 4 weeks pre-operative, 8 weeks post-operative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anikar Chhabra, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40101801 | Derived | McGurren DP, Glattke KE, Chhabra A, Boddu SP, Poon SK, Flug JA, Brinkman JC, Goetzinger S, Lee JE, Nocella A, Rogge J, De Luigi AJ. Assessment of Interrater Reliability for Interpretation of Musculoskeletal Ultrasound Imaging of the Quadriceps Femoris. Am J Phys Med Rehabil. 2025 Oct 1;104(10):906-910. doi: 10.1097/PHM.0000000000002731. Epub 2025 Mar 6. |
| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| SHAM Exercise Blood Flow Restriction training | Behavioral | While exercising Inflatable cuff, similar to a blood pressure cuff, applied to the proximal aspect of the femur of the affected lower extremity with limited inflation pressure to not occlude blood flow |
|
| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D000090003 | Blood Flow Restriction Therapy |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
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