Measures of Mitochondria Dysfunction in PD

Functional and Metabolomic Biomarkers of Mitochondrial Dysfunction in Parkinson's Disease

This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.

The goal of this study is to identify the unique signature of bioenergetic markers and mitochondrial (dys)function in muscle of individuals with PD, who are 65-85 of age, read and speak English, have a Hoehn & Yahr score between 2 and 3 (bilateral disease, not severely disabled) and have a clinical diagnosis of PD. Bioenergetic markers and muscle functional properties will be compared to a control dataset collected over the last few years from healthy elderly subjects in the same age range to provide a foundation for future intervention studies.

Inclusion Criteria:

• Age 65-85 years.
• Ability to attend a 3-hour study visit in Seattle, WA.
• Ability to read and speak English.
• Hoehn & Yahr Stage 2-3. (bilateral disease, not severely disabled.)

Exclusion Criteria:

• Any contra-indication to magnetic resonance imaging
• A history of epilepsy, stroke, brain surgery, or structural brain disease.
• The presence of other serious illnesses
• Current or recent enrollment in a clinical trial involving an investigational product or device.
• Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit.
• Current drug or alcohol use or dependence.
• Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
• Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
• Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.